Literature DB >> 21336302

p53 guards the metabolic pathway less travelled.

Eyal Gottlieb.   

Abstract

Glucose is an important source of energy and carbon, and is required for cell growth. As such, glucose utilization is increased in rapidly dividing cancer cells. The tumour suppressor p53 has now been reported to block a metabolic pathway (the pentose phosphate pathway) that diverts glucose away from bioenergetic into biosynthetic routes.
© 2011 Macmillan Publishers Limited. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21336302     DOI： 10.1038/ncb2177

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  13 in total

Review 1.  p53 regulation of metabolic pathways.

Authors:  Eyal Gottlieb; Karen H Vousden
Journal:  Cold Spring Harb Perspect Biol       Date:  2009-12-02       Impact factor: 10.005

2.  The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1.

Authors:  Angel Herrero-Mendez; Angeles Almeida; Emilio Fernández; Carolina Maestre; Salvador Moncada; Juan P Bolaños
Journal:  Nat Cell Biol       Date:  2009-05-17       Impact factor: 28.824

3.  Activation of a metabolic gene regulatory network downstream of mTOR complex 1.

Authors:  Katrin Düvel; Jessica L Yecies; Suchithra Menon; Pichai Raman; Alex I Lipovsky; Amanda L Souza; Ellen Triantafellow; Qicheng Ma; Regina Gorski; Stephen Cleaver; Matthew G Vander Heiden; Jeffrey P MacKeigan; Peter M Finan; Clary B Clish; Leon O Murphy; Brendan D Manning
Journal:  Mol Cell       Date:  2010-07-30       Impact factor: 17.970

4.  TIGAR, a p53-inducible regulator of glycolysis and apoptosis.

Authors:  Karim Bensaad; Atsushi Tsuruta; Mary A Selak; M Nieves Calvo Vidal; Katsunori Nakano; Ramon Bartrons; Eyal Gottlieb; Karen H Vousden
Journal:  Cell       Date:  2006-07-14       Impact factor: 41.582

Review 5.  The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes.

Authors:  Arnold J Levine; Anna M Puzio-Kuter
Journal:  Science       Date:  2010-12-03       Impact factor: 47.728

6.  p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase.

Authors:  Peng Jiang; Wenjing Du; Xingwu Wang; Anthony Mancuso; Xiang Gao; Mian Wu; Xiaolu Yang
Journal:  Nat Cell Biol       Date:  2011-02-20       Impact factor: 28.824

7.  Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment.

Authors:  Zachary T Schafer; Alexandra R Grassian; Loling Song; Zhenyang Jiang; Zachary Gerhart-Hines; Hanna Y Irie; Sizhen Gao; Pere Puigserver; Joan S Brugge
Journal:  Nature       Date:  2009-08-19       Impact factor: 49.962

Review 8.  Cytoplasmic functions of the tumour suppressor p53.

Authors:  Douglas R Green; Guido Kroemer
Journal:  Nature       Date:  2009-04-30       Impact factor: 49.962

Review 9.  Metabolic transformation in cancer.

Authors:  Daniel A Tennant; Raúl V Durán; Houda Boulahbel; Eyal Gottlieb
Journal:  Carcinogenesis       Date:  2009-03-25       Impact factor: 4.944

10.  Structural and biochemical studies of TIGAR (TP53-induced glycolysis and apoptosis regulator).

Authors:  Hua Li; Gerwald Jogl
Journal:  J Biol Chem       Date:  2008-11-17       Impact factor: 5.157
View more
  10 in total

1.  Exosomes mediated pentose phosphate pathway in ovarian cancer metastasis: a proteomics analysis.

Authors:  Huan Yi; Xiangqin Zheng; Jianrong Song; Rongkai Shen; Yanzhao Su; Danmei Lin
Journal:  Int J Clin Exp Pathol       Date:  2015-12-01

2.  Vital staining with iodine solution in oral cancer: iodine infiltration, cell proliferation, and glucose transporter 1.

Authors:  Tiepeng Xiao; Hiroshi Kurita; Tetsu Shimane; Yoshitaka Nakanishi; Takeshi Koike
Journal:  Int J Clin Oncol       Date:  2012-07-25       Impact factor: 3.402

3.  Altered glycometabolism affects both clinical features and prognosis of triple-negative and neoadjuvant chemotherapy-treated breast cancer.

Authors:  Tieying Dong; Xinmei Kang; Zhaoliang Liu; Shu Zhao; Wenjie Ma; Qijia Xuan; Hang Liu; Zhipeng Wang; Qingyuan Zhang
Journal:  Tumour Biol       Date:  2015-12-29

4.  Dysregulated lipid metabolism in cancer.

Authors:  Feng Zhang; Guangwei Du
Journal:  World J Biol Chem       Date:  2012-08-26

5.  Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia.

Authors:  M Christiane Brahimi-Horn; Sandra Lacas-Gervais; Ricardo Adaixo; Karine Ilc; Matthieu Rouleau; Annick Notte; Marc Dieu; Carine Michiels; Thibault Voeltzel; Véronique Maguer-Satta; Joffrey Pelletier; Marius Ilie; Paul Hofman; Bénédicte Manoury; Alexander Schmidt; Sebastian Hiller; Jacques Pouysségur; Nathalie M Mazure
Journal:  Mol Cell Biol       Date:  2015-02-17       Impact factor: 4.272

Review 6.  Metabolic Portraits of Breast Cancer by HR MAS MR Spectroscopy of Intact Tissue Samples.

Authors:  Tonje H Haukaas; Leslie R Euceda; Guro F Giskeødegård; Tone F Bathen
Journal:  Metabolites       Date:  2017-05-16

7.  MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect.

Authors:  Nataly Shtraizent; Charles DeRossi; Shikha Nayar; Ravi Sachidanandam; Liora S Katz; Adam Prince; Anna P Koh; Adam Vincek; Yoav Hadas; Yujin Hoshida; Donald K Scott; Efrat Eliyahu; Hudson H Freeze; Kirsten C Sadler; Jaime Chu
Journal:  Elife       Date:  2017-06-23       Impact factor: 8.140

8.  Role of PI3K-AKT-mTOR and Wnt Signaling Pathways in Transition of G1-S Phase of Cell Cycle in Cancer Cells.

Authors:  Lakshmipathi Vadlakonda; Mukesh Pasupuleti; Reddanna Pallu
Journal:  Front Oncol       Date:  2013-04-12       Impact factor: 6.244

9.  Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation.

Authors:  Zeqian Yu; Susu Zhao; Long Ren; Lishan Wang; Zhangjun Chen; Robert M Hoffman; Jiahua Zhou
Journal:  Oncotarget       Date:  2017-06-28

Review 10.  An Army Marches on Its Stomach: Metabolic Intermediates as Antimicrobial Mediators in Mycobacterium tuberculosis Infection.

Authors:  Emer E Hackett; Frederick J Sheedy
Journal:  Front Cell Infect Microbiol       Date:  2020-08-25       Impact factor: 5.293
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.