AIMS: Diabetic retinopathy (DR) is often asymptomatic even in its more advanced stages. Timely and repeated screening for DR avoids a late diagnosis of DR, but the high number of diabetic patients precludes a frequent screening; thus, the need for a method to identify patients at higher risk for DR becomes crucial. METHODS: A prospective analysis of 5034 type 2 diabetic patients followed from 1996 to 2007 and not affected by retinopathy at the time of the recruitment was performed. Patients were randomly divided (ratio 2:1) into two groups: the train data set and the test set (3327 and 1707 patients, respectively). Factors associated with the occurrence of DR were assessed by the Cox's proportional hazard model. RESULTS:Duration of diabetes, glycosylated hemoglobin, systolic blood Pressure, male gender, albuminuria and diabetes therapy other than diet were all significantly associated with the occurrence of DR. CONCLUSIONS: The nomogram could help in ranking the type 2 diabetic patients at higher risk to develop DR and thus with a need for more frequent ophthalmologic checks, without enhancing neither the time nor the costs.
RCT Entities:
AIMS: Diabetic retinopathy (DR) is often asymptomatic even in its more advanced stages. Timely and repeated screening for DR avoids a late diagnosis of DR, but the high number of diabeticpatients precludes a frequent screening; thus, the need for a method to identify patients at higher risk for DR becomes crucial. METHODS: A prospective analysis of 5034 type 2 diabeticpatients followed from 1996 to 2007 and not affected by retinopathy at the time of the recruitment was performed. Patients were randomly divided (ratio 2:1) into two groups: the train data set and the test set (3327 and 1707 patients, respectively). Factors associated with the occurrence of DR were assessed by the Cox's proportional hazard model. RESULTS: Duration of diabetes, glycosylated hemoglobin, systolic blood Pressure, male gender, albuminuria and diabetes therapy other than diet were all significantly associated with the occurrence of DR. CONCLUSIONS: The nomogram could help in ranking the type 2 diabeticpatients at higher risk to develop DR and thus with a need for more frequent ophthalmologic checks, without enhancing neither the time nor the costs.
Authors: M Rinaldi; R dell'Omo; F Morescalchi; F Semeraro; E Gambicorti; F Cacciatore; F Chiosi; C Costagliola Journal: Int Ophthalmol Date: 2017-10-31 Impact factor: 2.031
Authors: Yiyuan Liu; Minghui Wang; Andrew D Morris; Alex S F Doney; Graham P Leese; Ewan R Pearson; Colin N A Palmer Journal: Diabetes Care Date: 2013-10-29 Impact factor: 19.112
Authors: Sian Taylor-Phillips; Hema Mistry; Rachael Leslie; Dan Todkill; Alexander Tsertsvadze; Martin Connock; Aileen Clarke Journal: Br J Ophthalmol Date: 2015-01-13 Impact factor: 4.638