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Literature DB >> 21334725

Determination of 14 monoalkyl phosphates, dialkyl phosphates and dialkyl thiophosphates by LC-MS/MS in human urinary samples.

Thorsten Reemtsma¹, Jana Lingott, Stefanie Roegler.

Abstract

Human urine was analyzed for nine dialkyl (DAP) and five monoalkyl phosphates (MAP) by LC-MS/MS. Some phosphoric acid esters are industrial chemicals and other hydrolysis products of trialkyl or triaryl phosphates, used as pesticides, flame retardants or plasticizers. Five MAP and two DAP were detected here for the first time in human urine. Monobutyl, diethyl, diphenyl and diethylhexyl phosphate were determined with median concentrations in the μg/L-range. The total urinary concentration of the 14 DAP and MAP summed up to a median of 20μg/L. Inclusion of MAP in future biomonitoring studies should provide a more comprehensive picture of the exposure of humans to organophosphorus compounds.

Entities: Chemical Disease Species

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Year: 2011 PMID： 21334725 DOI： 10.1016/j.scitotenv.2011.01.032

Source DB: PubMed Journal: Sci Total Environ ISSN： 0048-9697 Impact factor: 7.963

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Cited

15 in total

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