Literature DB >> 21334614

The first successful paternity through in vitro fertilization-intracytoplasmic sperm injection with a man homozygous for the 5α-reductase-2 gene mutation.

Hey-Joo Kang1, Julianne Imperato-McGinley, Yuan-Shan Zhu, Li-Qun Cai, Peter Schlegel, Gianpiero Palermo, Zev Rosenwaks.   

Abstract

OBJECTIVE: To report a case of successful paternity from a male homozygous for 5α-reductase-2 deficiency.
DESIGN: Case report.
SETTING: Academic center, division of reproductive endocrinology. PATIENT(S): A 45-year-old Dominican man and his 32-year-old wife. INTERVENTION(S): In vitro fertilization and intracytoplasmic sperm injection. MAIN OUTCOME MEASURE(S): Pregnancy. RESULT(S): Viable twin gestation. CONCLUSION(S): Men homozygous for 5α-reductase-2 deficiency can achieve biologic paternity through in vitro fertilization with intracytoplasmic sperm injection despite severely abnormal semen parameters.
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21334614     DOI： 10.1016/j.fertnstert.2011.01.121

Source DB:  PubMed          Journal:  Fertil Steril        ISSN： 0015-0282            Impact factor:   7.329


  6 in total

Review 1.  The effect of 5α-reductase-2 deficiency on human fertility.

Authors:  Hey-Joo Kang; Julianne Imperato-McGinley; Yuan-Shan Zhu; Zev Rosenwaks
Journal:  Fertil Steril       Date:  2014-01-08       Impact factor: 7.329

2.  Histological analysis of testes in patients with 5 alpha-reductase deficiency type 2: Comparison with cryptorchid testes in patients without endocrinological abnormalities and a review of the literature.

Authors:  Tamaki Wada; Chihiro Ichikawa; Makoto Takeuchi; Futoshi Matsui; Fumi Matsumoto; Shinobu Ida; Yuri Etani; Masanobu Kawai
Journal:  Clin Pediatr Endocrinol       Date:  2022-06-03

Review 3.  Gender Development in 46,XY DSD: Influences of Chromosomes, Hormones, and Interactions with Parents and Healthcare Professionals.

Authors:  Amy B Wisniewski
Journal:  Scientifica (Cairo)       Date:  2012-09-19

4.  Testicular histological and immunohistochemical aspects in a post-pubertal patient with 5 alpha-reductase type 2 deficiency: case report and review of the literature in a perspective of evaluation of potential fertility of these patients.

Authors:  Lavinia Vija; Sophie Ferlicot; Diana Paun; Hélène Bry-Gauillard; Gabriela Berdan; Issam Abd-Alsamad; Marc Lombès; Jacques Young
Journal:  BMC Endocr Disord       Date:  2014-05-23       Impact factor: 2.763

5.  Preservation of Fertility Potential for Gender and Sex Diverse Individuals.

Authors:  Emilie K Johnson; Courtney Finlayson
Journal:  Transgend Health       Date:  2016-01-01

Review 6.  Disorders of Sex Development-Novel Regulators, Impacts on Fertility, and Options for Fertility Preservation.

Authors:  Nathalia Lisboa Gomes; Tarini Chetty; Anne Jorgensen; Rod T Mitchell
Journal:  Int J Mol Sci       Date:  2020-03-26       Impact factor: 6.208
  6 in total

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