| Literature DB >> 21334417 |
Zhen Huang1, Xiao-Ming Zhong, Zhao-Yi Li, Chun-Rong Feng, Ai-Juan Pan, Qing-Qiu Mao.
Abstract
A rat model of depression has been recently developed using exogenous corticosterone (CORT) administration. This study aimed to examine the antidepressant-like effect and the possible mechanisms of curcumin in a CORT-induced depression model in rats. The results showed that 3-week CORT injections caused depression-like behavior in rats, as indicated by the significant decrease in sucrose consumption and increase in immobility time in the forced swim test. Repeated CORT injections also significantly decreased brain-derived neurotrophic factor (BDNF) protein levels in the hippocampus and frontal cortex of the rats. Treatment of the rats with curcumin significantly suppressed the depression-like behavior and the decrease in brain BDNF levels induced by the repeated CORT injections. The results suggest that curcumin produces an antidepressant-like effect in CORT-treated rats, which is possibly mediated by increasing BDNF expression in the hippocampus and frontal cortex.Entities:
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Year: 2011 PMID： 21334417 DOI： 10.1016/j.neulet.2011.02.030
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046