| Literature DB >> 21334118 |
Rosa M Claramunt1, Concepción López, Ana López, Carlos Pérez-Medina, Marta Pérez-Torralba, Ibon Alkorta, José Elguero, Germaine Escames, Darío Acuña-Castroviejo.
Abstract
The inhibition of neuronal and inducible nitric oxide synthases (nNOS and iNOS) by a series of 36 indazoles has been evaluated, showing that most of the assayed derivatives are better iNOS than nNOS inhibitors. A parabolic model relating the iNOS inhibition percentage with the difference, E(rel), between stacking and apical interaction energies of indazoles with the active site of the NOS enzyme has been established.Entities:
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Year: 2011 PMID： 21334118 DOI： 10.1016/j.ejmech.2011.01.027
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514