Chapter 7--interindividual variability and its implications for locomotor adaptation following peripheral nerve and/or spinal cord injury.

Following injury to the nervous system, there is a range of possible functional outcomes that can only be partly explained by the extent of injury. Moreover, treatments effective in certain individuals might not work in others. Why such variability from one individual to another, in terms of functional outcomes and responsiveness to a given treatment following a similar injury? The answer to that question is not simple, and to begin to answer we must first consider that individuals of the same species can be quite variable in terms of neuronal circuit parameters involved in performing a given task. Interindividual variability can be subtle but the term "variability" in this chapter will be used to denote marked differences between individuals at the systems level (e.g., spinal reflexes, bursts of muscle activity, kinematics) during the same motor behavior, with an emphasis on locomotion. Injury to any level of the nervous system, in turn, can further compound this variability by altering spared neuronal connections. The aim of the present chapter is to (1) review studies that have investigated interindividual variability, (2) review studies that have described variable adaptive mechanisms following spinal and/or peripheral nerve lesions during locomotion, and (3) discuss the implications of intersubject variability for locomotor adaptation.