| Literature DB >> 21333600 |
Frank L van de Veerdonk1, Mihai G Netea, Charles A Dinarello, Leo A B Joosten.
Abstract
Interleukin-1β (IL-1β) and IL-18 contribute to host defense against infection by augmenting antimicrobial properties of phagocytes and initiating Th1 and Th17 adaptive immune responses. Protein complexes called inflammasomes activate intracellular caspase-1 autocatalytically, which cleaves the inactive precursors of IL-1β and IL-18 into bioactive cytokines. In this review, we discuss the controversies regarding inflammasome activation and the role of the inflammasome during infection. We highlight alternative mechanisms for processing IL-1β and IL-18 during infection, which involve extracellular cleavage of the inactive cytokines by neutrophil-derived serine proteases or proteases released from cytotoxic T cells.Entities:
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Year: 2011 PMID： 21333600 DOI： 10.1016/j.it.2011.01.003
Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687