BACKGROUND: A newly acquired rhesus macaque was suffering from rapid destruction of the left cheek caused by necrotizing stomatitis. METHODS: To restore reconstructive surgery and intensive care with antibiotics, wound protection, wound healing agents, and debridement were applied. RESULTS: Staphylococcus aureus and Enterococcus faecalis were isolated from the culture of the lesion, and the antibiotic susceptibility test revealed methicillin-resistant Staphylococcus aureus infection. Vancomycin and ampicillin-sulbactam effectively treated the bacterial infections, and reconstructive surgery was performed once the infection was cleared. Topical application of recombinant human epidermal growth factor (rhEGF) was useful to treat exposed wound of the noma lesion. CONCLUSIONS: Simian noma associated with methicillin-resistant Staphylococcus aureus (MRSA) had not previously been reported in non-human primates. Although noma associated with MRSA is hard to cure because of its rapid and destructive progress, the aggressive therapy used in this study led to the successful resolution of an acute necrotic stomatitis lesion in a rhesus macaque.
BACKGROUND: A newly acquired rhesus macaque was suffering from rapid destruction of the left cheek caused by necrotizing stomatitis. METHODS: To restore reconstructive surgery and intensive care with antibiotics, wound protection, wound healing agents, and debridement were applied. RESULTS:Staphylococcus aureus and Enterococcus faecalis were isolated from the culture of the lesion, and the antibiotic susceptibility test revealed methicillin-resistant Staphylococcus aureus infection. Vancomycin and ampicillin-sulbactam effectively treated the bacterial infections, and reconstructive surgery was performed once the infection was cleared. Topical application of recombinant humanepidermal growth factor (rhEGF) was useful to treat exposed wound of the noma lesion. CONCLUSIONS: Simian noma associated with methicillin-resistant Staphylococcus aureus (MRSA) had not previously been reported in non-human primates. Although noma associated with MRSA is hard to cure because of its rapid and destructive progress, the aggressive therapy used in this study led to the successful resolution of an acute necrotic stomatitis lesion in a rhesus macaque.
Authors: Olusegun O Soge; David No; Karen E Michael; Jennifer Dankoff; Jennifer Lane; Keith Vogel; Jeremy Smedley; Marilyn C Roberts Journal: J Antimicrob Chemother Date: 2016-07-20 Impact factor: 5.790
Authors: Tae M Kim; Hyojun Park; Kyo W Lee; Eun W Choi; Sang H Moon; Yong S Lee; Kahee Cho; Wan J Park; Jae B Park; Sung J Kim Journal: Comp Med Date: 2017-08-01 Impact factor: 0.982
Authors: Abigail W Greenstein; Susan Boyle-Vavra; Carol W Maddox; Xiwei Tang; Lisa C Halliday; Jeffrey D Fortman Journal: Comp Med Date: 2019-08-02 Impact factor: 0.982
Authors: Madikay Senghore; Sion C Bayliss; Brenda A Kwambana-Adams; Ebenezer Foster-Nyarko; Jainaba Manneh; Michel Dione; Henry Badji; Chinelo Ebruke; Emma L Doughty; Harry A Thorpe; Anna J Jasinska; Christopher A Schmitt; Jennifer D Cramer; Trudy R Turner; George Weinstock; Nelson B Freimer; Mark J Pallen; Edward J Feil; Martin Antonio Journal: Appl Environ Microbiol Date: 2016-09-16 Impact factor: 4.792