PURPOSE: To investigate whether normal tension glaucoma (NTG) is associated with increased risk of developing dementia/Alzheimer disease (AD). METHODS: A total of 69 patients with NTG were identified in the case note files in the Glaucoma Clinic, University Hospital of Copenhagen (Rigshospitalet), Denmark from 1980 to 2001. The rate of a subsequent diagnosis of dementia as recorded in nationwide health care registers from 1980 to 2005 was estimated and compared with the rate for the general population [standard mortality rate (SMR) = observed number of cases of dementia/expected number of cases of dementia]. RESULTS: The 69 patients had a median age of 64 years (quartiles 57 and 73) at the time of the diagnosis, and the average follow-up period was 12.7 years. The SMR(dementia) was 0.20 (95% CI 0.01-1.11). No patient developed AD. CONCLUSION: Normal tension glaucoma was not associated with an increased risk of developing dementia/AD.
PURPOSE: To investigate whether normal tension glaucoma (NTG) is associated with increased risk of developing dementia/Alzheimer disease (AD). METHODS: A total of 69 patients with NTG were identified in the case note files in the Glaucoma Clinic, University Hospital of Copenhagen (Rigshospitalet), Denmark from 1980 to 2001. The rate of a subsequent diagnosis of dementia as recorded in nationwide health care registers from 1980 to 2005 was estimated and compared with the rate for the general population [standard mortality rate (SMR) = observed number of cases of dementia/expected number of cases of dementia]. RESULTS: The 69 patients had a median age of 64 years (quartiles 57 and 73) at the time of the diagnosis, and the average follow-up period was 12.7 years. The SMR(dementia) was 0.20 (95% CI 0.01-1.11). No patient developed AD. CONCLUSION:Normal tension glaucoma was not associated with an increased risk of developing dementia/AD.
Authors: Joanna M Jefferis; John-Paul Taylor; Joanna Collerton; Carol Jagger; Andrew Kingston; Karen Davies; Tom Kirkwood; Michael P Clarke Journal: Ophthalmic Epidemiol Date: 2013-04 Impact factor: 1.648
Authors: Ahmed Shamsul Arefin; Luke Mathieson; Daniel Johnstone; Regina Berretta; Pablo Moscato Journal: PLoS One Date: 2012-09-21 Impact factor: 3.240
Authors: Aditya V Belamkar; Sasha A Mansukhani; Rodolfo Savica; Matthew R Spiegel; David O Hodge; Arthur J Sit Journal: J Glaucoma Date: 2021-03-01 Impact factor: 2.290