BACKGROUND: Fanconi's anemia (FA) is a rare recessive genetic disorder characterized by bone marrow failure, developmental and congenital abnormalities, which frequently evolves to aplastic anemia and neoplasias, primarily acute leukemia and head-neck carcinomas. Risk of malignancies increases after hematopoietic stem cell transplantation (HSCT), and the role of human papillomavirus (HPV) in FA carcinogenesis have been proposed. OBJECTIVE: To investigate prevalence of oral HPV in FA patients without oral malignant lesions. MATERIALS AND METHODS: After oral examination, 76 subjects without detectable oral malignant lesions were included and classified in four groups: 20 FA submitted to HSCT (I), 22 FA not submitted to HSCT (II), 18 severe aplastic anemia (SAA) submitted to HSCT (III) and 16 healthy subjects (IV). Liquid-based cytology sampling, HPV screening by polymerase chain reaction and genotyping by reverse hybridization were performed. RESULTS: The HPV detection rates were: group I 35%, group II 27.3%, group III 38% and group IV 6.25%. Prevalence of high risk HPV types, mainly HPV16, was detected. Compared with control group, suggestions for increased likelihood of being HPV infected in SAA (OR = 9.55, 95% CI: 1.01-125.41) and FA patients submitted to HSCT (OR = 8.08, 0.83-72.29) emerged. CONCLUSION: Patients without oral malignant lesions submitted to HSCT, have high prevalence of oral HPV. HPV screening and close follow up should be considered in these patients.
BACKGROUND:Fanconi's anemia (FA) is a rare recessive genetic disorder characterized by bone marrow failure, developmental and congenital abnormalities, which frequently evolves to aplastic anemia and neoplasias, primarily acute leukemia and head-neck carcinomas. Risk of malignancies increases after hematopoietic stem cell transplantation (HSCT), and the role of human papillomavirus (HPV) in FA carcinogenesis have been proposed. OBJECTIVE: To investigate prevalence of oral HPV in FA patients without oral malignant lesions. MATERIALS AND METHODS: After oral examination, 76 subjects without detectable oral malignant lesions were included and classified in four groups: 20 FA submitted to HSCT (I), 22 FA not submitted to HSCT (II), 18 severe aplastic anemia (SAA) submitted to HSCT (III) and 16 healthy subjects (IV). Liquid-based cytology sampling, HPV screening by polymerase chain reaction and genotyping by reverse hybridization were performed. RESULTS: The HPV detection rates were: group I 35%, group II 27.3%, group III 38% and group IV 6.25%. Prevalence of high risk HPV types, mainly HPV16, was detected. Compared with control group, suggestions for increased likelihood of being HPV infected in SAA (OR = 9.55, 95% CI: 1.01-125.41) and FA patients submitted to HSCT (OR = 8.08, 0.83-72.29) emerged. CONCLUSION:Patients without oral malignant lesions submitted to HSCT, have high prevalence of oral HPV. HPV screening and close follow up should be considered in these patients.
Authors: R L Winer; C E Huang; S Cherne; J E Stern; M S Butsch Kovacic; P A Mehta; S L Sauter; D A Galloway; R A Katzenellenbogen Journal: Oral Dis Date: 2014-09-18 Impact factor: 3.511
Authors: Elizabeth E Hoskins; Richard J Morreale; Stephen P Werner; Jennifer M Higginbotham; Laimonis A Laimins; Paul F Lambert; Darron R Brown; Maura L Gillison; Gerard J Nuovo; David P Witte; Mi-Ok Kim; Stella M Davies; Parinda A Mehta; Melinda Butsch Kovacic; Kathryn A Wikenheiser-Brokamp; Susanne I Wells Journal: J Virol Date: 2012-05-23 Impact factor: 5.103
Authors: Sharon L Sauter; Susanne I Wells; Xue Zhang; Elizabeth E Hoskins; Stella M Davies; Kasiani C Myers; Robin Mueller; Gitika Panicker; Elizabeth R Unger; Umasundari Sivaprasad; Darron R Brown; Parinda A Mehta; Melinda Butsch Kovacic Journal: Cancer Epidemiol Biomarkers Prev Date: 2015-03-25 Impact factor: 4.254
Authors: Timothy M Chlon; Elizabeth E Hoskins; Christopher N Mayhew; Kathryn A Wikenheiser-Brokamp; Stella M Davies; Parinda Mehta; Kasiani C Myers; James M Wells; Susanne I Wells Journal: J Virol Date: 2014-07-16 Impact factor: 5.103