| Literature DB >> 21331083 |
Edward A Neuwelt1, Björn Bauer, Christoph Fahlke, Gert Fricker, Constantino Iadecola, Damir Janigro, Luc Leybaert, Zoltán Molnár, Martha E O'Donnell, John T Povlishock, Norman R Saunders, Frank Sharp, Danica Stanimirovic, Ryan J Watts, Lester R Drewes.
Abstract
The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and--when barrier integrity is impaired--in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.Entities:
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Year: 2011 PMID： 21331083 PMCID： PMC3335275 DOI： 10.1038/nrn2995
Source DB: PubMed Journal: Nat Rev Neurosci ISSN： 1471-003X Impact factor: 34.870