D Bergqvist1. 1. Department of Surgical Sciences, Section of Surgery, Uppsala University Hospital, SE 751 85 Uppsala, Sweden. david.bergqvist@surgsci.uu.se
Abstract
INTRODUCTION: Is it possible by pharmacological methods to attenuate the expansion rate of abdominal aortic aneurysms? METHOD: An Internet-based systematic literature search was performed to identify published reports on pharmacological methods to influence aneurysmal expansion rate. RESULTS: Of an original 450 articles, 21 remained to review: they included 15 cohort studies with 12,321 patients and seven randomised clinical trials (RCTs) with 1069 patients. Most studies are performed without a pre-study sample size calculation. There is no consistent pattern of pharmacological influence on expansion rate, but statins, non-steroidal anti-inflammatory drugs (NSAIDs) and macrolides should be further evaluated. CONCLUSION: Properly designed RCTs are needed before conclusions can be drawn on the possibility to pharmacologically attenuate aneurysmal expansion and prevent rupture.
INTRODUCTION: Is it possible by pharmacological methods to attenuate the expansion rate of abdominal aortic aneurysms? METHOD: An Internet-based systematic literature search was performed to identify published reports on pharmacological methods to influence aneurysmal expansion rate. RESULTS: Of an original 450 articles, 21 remained to review: they included 15 cohort studies with 12,321 patients and seven randomised clinical trials (RCTs) with 1069 patients. Most studies are performed without a pre-study sample size calculation. There is no consistent pattern of pharmacological influence on expansion rate, but statins, non-steroidal anti-inflammatory drugs (NSAIDs) and macrolides should be further evaluated. CONCLUSION: Properly designed RCTs are needed before conclusions can be drawn on the possibility to pharmacologically attenuate aneurysmal expansion and prevent rupture.
Authors: Wojciech Mrowiecki; Agnieszka Sagan; Bartłomiej Guzik; Tomasz Sliwa; Adam Ignacak; Tomasz Mrowiecki; Tomasz J Guzik Journal: Arch Med Sci Date: 2014-12-22 Impact factor: 3.318
Authors: Judith Marsman; Gregory Gimenez; Robert C Day; Julia A Horsfield; Gregory T Jones Journal: Hum Mol Genet Date: 2020-03-13 Impact factor: 6.150
Authors: Konrad Salata; Muzammil Syed; Mohamad A Hussain; Charles de Mestral; Elisa Greco; Muhammad Mamdani; Jack V Tu; Thomas L Forbes; Deepak L Bhatt; Subodh Verma; Mohammed Al-Omran Journal: J Am Heart Assoc Date: 2018-10-02 Impact factor: 5.501