Literature DB >> 21330134

Discovery of new inhibitor for PDE3 by virtual screening.

Ki Young Kim1, Hyuk Lee, Sung-Eun Yoo, Seong Hwan Kim, Nam Sook Kang.   

Abstract

In this work, we tried to find a new scaffold for a PDE3 using virtual screening for the obesity treatment. We first analyzed structural features for the known PDE3 inhibitors based on the PDE3B-ligand complex structure, and then carried out a docking study based on PDE3B 3D structure. We obtained a compound as potent PDE3 inhibitor stimulating lipolysis in murine adipocytes and human adipocytes.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21330134     DOI： 10.1016/j.bmcl.2011.01.120

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure.

Authors:  Chimed Jansen; Huanchen Wang; Albert J Kooistra; Chris de Graaf; Kristina M Orrling; Hermann Tenor; Thomas Seebeck; David Bailey; Iwan J P de Esch; Hengming Ke; Rob Leurs
Journal:  J Med Chem       Date:  2013-03-01       Impact factor: 7.446

Review 2.  Therapeutic targeting of 3',5'-cyclic nucleotide phosphodiesterases: inhibition and beyond.

Authors:  George S Baillie; Gonzalo S Tejeda; Michy P Kelly
Journal:  Nat Rev Drug Discov       Date:  2019-08-06       Impact factor: 84.694

3.  Efficient Synthesis of Chiral Trisubstituted 1,2-Allenyl Ketones by Catalytic Asymmetric Conjugate Addition of Malonic Esters to Enynes.

Authors:  Qian Yao; Yuting Liao; Lili Lin; Xiaobin Lin; Jie Ji; Xiaohua Liu; Xiaoming Feng
Journal:  Angew Chem Int Ed Engl       Date:  2015-12-22       Impact factor: 15.336
  3 in total

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