[Biochemical parameters and prediction of the development of glaucoma in patients with progressive myopia].

Examinations were made in 3 groups of patients aged 15 to 27 years: 1) patients with rapidly progressive high-grade myopia; 2) those with slowly progressive high-grade myopia; 3) healthy individuals (controls). Groups 1 and 2 patients had elevated levels of lactic and pyruvic acids along with the decreased activity of the antioxidant system in the tear. Thus, a combination of indicators, such as a rise in hypoxia index by more than 1.0 and a decrease in the lacrimal fluid content of superoxide dismutase by more than 40%, may be a predictor of glaucoma in persons with rapidly progressive high-grade myopia.