Literature DB >> 21328449

Nuclear protein isoforms: implications for cancer diagnosis and therapy.

Fei Shen1, Kashif Z Kirmani, Zhimin Xiao, Benjamin H Thirlby, Robert J Hickey, Linda H Malkas.   

Abstract

Post-translational modifications (PTMs) of nuclear proteins play essential roles in the regulation of gene transcription and signal transduction pathways. Numerous studies have demonstrated a correlation between specific nuclear protein isoforms and cellular malignant process. This communication reviews the impact of major PTM events such as phosphorylation, acetylation, methylation, ubiquitination, and sumoylation on several important nuclear proteins including p53, histones, proliferating cellular nuclear antigen (PCNA), and retinoblastoma protein (Rb) in the process. In addition, the implications of the PTMs as cancer biomarkers and therapeutic targets are considered.
Copyright © 2010 Wiley-Liss, Inc.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21328449      PMCID： PMC3080020          DOI： 10.1002/jcb.23002

Source DB:  PubMed          Journal:  J Cell Biochem        ISSN： 0730-2312            Impact factor:   4.429


  46 in total

1.  Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo.

Authors:  Julia K Kurash; Hong Lei; Qiong Shen; Wendy L Marston; Brian W Granda; Hong Fan; Daniel Wall; En Li; François Gaudet
Journal:  Mol Cell       Date:  2008-02-15       Impact factor: 17.970

Review 2.  Chemical regulation of epigenetic modifications: opportunities for new cancer therapy.

Authors:  Yujun George Zheng; Jiang Wu; Ziyue Chen; Masha Goodman
Journal:  Med Res Rev       Date:  2008-09       Impact factor: 12.944

3.  Acetylation is indispensable for p53 activation.

Authors:  Yi Tang; Wenhui Zhao; Yue Chen; Yingming Zhao; Wei Gu
Journal:  Cell       Date:  2008-05-16       Impact factor: 41.582

4.  A cancer-associated PCNA expressed in breast cancer has implications as a potential biomarker.

Authors:  Linda H Malkas; Brittney Shea Herbert; Waleed Abdel-Aziz; Lacey E Dobrolecki; Yang Liu; Beamon Agarwal; Derek Hoelz; Sunil Badve; Lauren Schnaper; Randy J Arnold; Yehia Mechref; Milos V Novotny; Patrick Loehrer; Robert J Goulet; Robert J Hickey
Journal:  Proc Natl Acad Sci U S A       Date:  2006-12-11       Impact factor: 11.205

Review 5.  Ubiquitin-like protein modifications in prostate and breast cancer.

Authors:  Fangting Wu; Yin-Yuan Mo
Journal:  Front Biosci       Date:  2007-01-01

6.  Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma.

Authors:  Elise A Olsen; Youn H Kim; Timothy M Kuzel; Theresa R Pacheco; Francine M Foss; Sareeta Parker; Stanley R Frankel; Cong Chen; Justin L Ricker; Jean Marie Arduino; Madeleine Duvic
Journal:  J Clin Oncol       Date:  2007-06-18       Impact factor: 44.544

7.  Cyclic AMP-responsive element binding protein- and nuclear factor-kappaB-regulated CXC chemokine gene expression in lung carcinogenesis.

Authors:  Hongxia Sun; Wen-Cheng Chung; Seung-Hee Ryu; Zhenlin Ju; Hai T Tran; Edward Kim; Jonathan M Kurie; Ja Seok Koo
Journal:  Cancer Prev Res (Phila)       Date:  2008-10

8.  Modulation of p53 function by SET8-mediated methylation at lysine 382.

Authors:  Xiaobing Shi; Ioulia Kachirskaia; Hiroshi Yamaguchi; Lisandra E West; Hong Wen; Evelyn W Wang; Sucharita Dutta; Ettore Appella; Or Gozani
Journal:  Mol Cell       Date:  2007-08-17       Impact factor: 17.970

Review 9.  Histone deacetylase inhibitors: molecular mechanisms of action.

Authors:  W S Xu; R B Parmigiani; P A Marks
Journal:  Oncogene       Date:  2007-08-13       Impact factor: 9.867

Review 10.  Molecular basis for sunitinib efficacy and future clinical development.

Authors:  Sandrine Faivre; George Demetri; William Sargent; Eric Raymond
Journal:  Nat Rev Drug Discov       Date:  2007-09       Impact factor: 84.694
View more
  11 in total

1.  SAHA inhibits the growth of colon tumors by decreasing histone deacetylase and the expression of cyclin D1 and survivin.

Authors:  Jong-Shiaw Jin; Tang-Yi Tsao; Pei-Chang Sun; Cheng-Ping Yu; Ching Tzao
Journal:  Pathol Oncol Res       Date:  2012-01-20       Impact factor: 3.201

Review 2.  Human T-lymphotropic virus proteins and post-translational modification pathways.

Authors:  Carlo Bidoia
Journal:  World J Virol       Date:  2012-08-12

3.  Interlaboratory reproducibility of selective reaction monitoring assays using multiple upfront analyte enrichment strategies.

Authors:  Amol Prakash; Taha Rezai; Bryan Krastins; David Sarracino; Michael Athanas; Paul Russo; Hui Zhang; Yuan Tian; Yan Li; Vathany Kulasingam; Andrei Drabovich; Christopher R Smith; Ihor Batruch; Paul E Oran; Claudia Fredolini; Alessandra Luchini; Lance Liotta; Emanuel Petricoin; Eleftherios P Diamandis; Daniel W Chan; Randall Nelson; Mary F Lopez
Journal:  J Proteome Res       Date:  2012-07-03       Impact factor: 4.466

Review 4.  Mass spectrometry-based proteomics: existing capabilities and future directions.

Authors:  Thomas E Angel; Uma K Aryal; Shawna M Hengel; Erin S Baker; Ryan T Kelly; Errol W Robinson; Richard D Smith
Journal:  Chem Soc Rev       Date:  2012-04-13       Impact factor: 54.564

5.  SFPQ Promotes Lung Cancer Malignancy via Regulation of CD44 v6 Expression.

Authors:  Libang Yang; Jianbo Yang; Blake Jacobson; Adam Gilbertsen; Karen Smith; LeeAnn Higgins; Candace Guerrero; Hong Xia; Craig A Henke; Jizhen Lin
Journal:  Front Oncol       Date:  2022-05-30       Impact factor: 5.738

6.  Altered gene expression patterns during the initiation and promotion stages of neonatally diethylstilbestrol-induced hyperplasia/dysplasia/neoplasia in the hamster uterus.

Authors:  William J Hendry; Hussam Y Hariri; Imala D Alwis; Sumedha S Gunewardena; Isabel R Hendry
Journal:  Reprod Toxicol       Date:  2014-09-19       Impact factor: 3.143

7.  Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma.

Authors:  Po-Jui Chang; Pankaj K Bhavsar; Charalambos Michaeloudes; Nadia Khorasani; Kian Fan Chung
Journal:  J Allergy Clin Immunol       Date:  2012-09-01       Impact factor: 10.793

8.  Analysis of STAT3 post-translational modifications (PTMs) in human prostate cancer with different Gleason Score.

Authors:  Rossana Cocchiola; Donatella Romaniello; Caterina Grillo; Fabio Altieri; Marcello Liberti; Fabio Massimo Magliocca; Silvia Chichiarelli; Ilaria Marrocco; Giuseppe Borgoni; Giacomo Perugia; Margherita Eufemi
Journal:  Oncotarget       Date:  2017-06-27

Review 9.  Taking a holistic view of PEST-containing nuclear protein (PCNP) in cancer biology.

Authors:  Attia Afzal; Muhammad Sarfraz; Guang-Lei Li; Shao-Ping Ji; Shao-Feng Duan; Nazeer Hussain Khan; Dong-Dong Wu; Xin-Ying Ji
Journal:  Cancer Med       Date:  2019-09-05       Impact factor: 4.452

10.  Limonin inhibits angiogenesis and metastasis of human breast cancer cells by suppressing the VEGFR2/IGFR1-mediated STAT3 signaling pathway.

Authors:  Jing Chen; Bo-Xia Liu; Qin Shen; Na Li; Jun Ling; Min Xiao; Hai-Yan Jiao; Tao Li
Journal:  Transl Cancer Res       Date:  2020-11       Impact factor: 1.241
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.