Literature DB >> 21328317

Development of a dichloroacetic acid-hemoglobin conjugate as a potential targeted anti-cancer therapeutic.

Ning Zhang1, Andre F Palmer.   

Abstract

This work focuses on conjugating the anti-cancer drug dichloroacetic acid (DCA) to the monocyte/macrophage targeting protein hemoglobin (Hb). The DCA-Hb conjugate carries approximately 12 DCA molecules per Hb tetramer, and binds to haptoglobin (Hp) forming stable DCA-Hb-Hp complexes, in a similar manner to unmodified Hb. The results of this study show that DCA-Hb-Hp is taken up by the monocytic cancer cell line THP-1, where it depolarizes the mitochondrial membrane potential, thereby inhibiting cancerous cell growth at a comparable level to free DCA. Taken together, the results of this study show promise for the use of the DCA-Hb conjugate as a potential therapeutic to treat monocytic leukemia.
Copyright © 2011 Wiley Periodicals, Inc.

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Year:  2011        PMID： 21328317     DOI： 10.1002/bit.23071

Source DB:  PubMed          Journal:  Biotechnol Bioeng        ISSN： 0006-3592            Impact factor:   4.530


  10 in total

1.  Liposomes surface conjugated with human hemoglobin target delivery to macrophages.

Authors:  Ning Zhang; Andre F Palmer
Journal:  Biotechnol Bioeng       Date:  2011-11-06       Impact factor: 4.530

2.  AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress.

Authors:  Shrivani Sriskanthadevan; Danny V Jeyaraju; Timothy E Chung; Swayam Prabha; Wei Xu; Marko Skrtic; Bozhena Jhas; Rose Hurren; Marcela Gronda; Xiaoming Wang; Yulia Jitkova; Mahadeo A Sukhai; Feng-Hsu Lin; Neil Maclean; Rob Laister; Carolyn A Goard; Peter J Mullen; Stephanie Xie; Linda Z Penn; Ian M Rogers; John E Dick; Mark D Minden; Aaron D Schimmer
Journal:  Blood       Date:  2015-01-28       Impact factor: 22.113

Review 3.  Restoration of mitochondria function as a target for cancer therapy.

Authors:  Tariq A Bhat; Sandeep Kumar; Ajay K Chaudhary; Neelu Yadav; Dhyan Chandra
Journal:  Drug Discov Today       Date:  2015-03-09       Impact factor: 7.851

Review 4.  Chemical metabolic inhibitors for the treatment of blood-borne cancers.

Authors:  Martin Villalba; Nuria Lopez-Royuela; Ewelina Krzywinska; Moeez G Rathore; Robert A Hipskind; Houda Haouas; Nerea Allende-Vega
Journal:  Anticancer Agents Med Chem       Date:  2014-02       Impact factor: 2.505

5.  Low modulus biomimetic microgel particles with high loading of hemoglobin.

Authors:  Kai Chen; Timothy J Merkel; Ashish Pandya; Mary E Napier; J Christopher Luft; Will Daniel; Sergei Sheiko; Joseph M DeSimone
Journal:  Biomacromolecules       Date:  2012-08-17       Impact factor: 6.988

Review 6.  Harnessing molecular recognition for localized drug delivery.

Authors:  Renjie Liu; Ran Zuo; Gregory A Hudalla
Journal:  Adv Drug Deliv Rev       Date:  2021-01-20       Impact factor: 15.470

7.  Acid Denaturation Inducing Self-Assembly of Curcumin-Loaded Hemoglobin Nanoparticles.

Authors:  Kaikai Wang; Juan Wang; Wenwen Hu; Yifan Zhang; Feng Zhi; Zaigang Zhou; Jinhui Wu; Yiqiao Hu
Journal:  Materials (Basel)       Date:  2015-12-11       Impact factor: 3.623

Review 8.  Role and Mechanisms of Tumor-Associated Macrophages in Hematological Malignancies.

Authors:  Yutong Xie; Huan Yang; Chao Yang; Liren He; Xi Zhang; Li Peng; Hongbin Zhu; Lei Gao
Journal:  Front Oncol       Date:  2022-07-07       Impact factor: 5.738

9.  Biodistribution PET/CT Study of Hemoglobin-DFO-89Zr Complex in Healthy and Lung Tumor-Bearing Mice.

Authors:  Łukasz Kiraga; Gabriele Cerutti; Agata Braniewska; Damian Strzemecki; Zuzanna Sas; Alberto Boffi; Carmelinda Savino; Linda Celeste Montemiglio; Daniel Turnham; Gillian Seaton; Alessandra Bonamore; Richard Clarkson; Adam M Dabkowski; Stephen J Paisey; Bartłomiej Taciak; Paulina Kucharzewska; Tomasz P Rygiel; Magdalena Król
Journal:  Int J Mol Sci       Date:  2020-07-15       Impact factor: 5.923

10.  The discovery of berberine erythrocyte-hemoglobin self-assembly delivery system: a neglected carrier underlying its pharmacokinetics.

Authors:  Qiuxia Yu; Minhua Li; Hanbin Chen; Lieqiang Xu; Juanjuan Cheng; Guoshu Lin; Yuhong Liu; Ziren Su; Xiaobo Yang; Yucui Li; Jiannan Chen; Jianhui Xie
Journal:  Drug Deliv       Date:  2022-12       Impact factor: 6.419
  10 in total

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