Literature DB >> 21327916

Novel therapy for myocardial infarction: can HGF/Met be beneficial?

V Sala1, T Crepaldi.   

Abstract

Myocardial infarction (MI) is a leading cause of hospitalization worldwide. A recently developed strategy to improve the management of MI is based on the use of growth factors which are able to enhance the intrinsic capacity of the heart to repair itself or regenerate after damage. Among others, hepatocyte growth factor (HGF) has been proposed as a modulator of cardiac repair of damage due to the pleiotropic effects elicited by Met receptor stimulation. In this review we describe the mechanistic basis for autocrine and paracrine protection of HGF in the injured heart. We also analyse the role of HGF/Met in stem cell maintenance and in stem cell therapies for MI. Finally, we summarize the most significant results on the use of HGF in experimental models of heart injury and discuss the potential of the molecule for treating ischaemic heart disease in humans.

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Year:  2011        PMID： 21327916     DOI： 10.1007/s00018-011-0633-6

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  174 in total

1.  HGF reduces advancing lung fibrosis in mice: a potential role for MMP-dependent myofibroblast apoptosis.

Authors:  Shinya Mizuno; Kunio Matsumoto; Ming-Yue Li; Toshikazu Nakamura
Journal:  FASEB J       Date:  2005-01-21       Impact factor: 5.191

2.  Hepatocyte growth factor and c-Met expression in pericytes: implications for atherosclerotic plaque development.

Authors:  Y Liu; F L Wilkinson; J P Kirton; M Jeziorska; H Iizasa; Y Sai; E Nakashima; A M Heagerty; A E Canfield; M Y Alexander
Journal:  J Pathol       Date:  2007-05       Impact factor: 7.996

3.  Chimerism of the transplanted heart.

Authors:  Federico Quaini; Konrad Urbanek; Antonio P Beltrami; Nicoletta Finato; Carlo A Beltrami; Bernardo Nadal-Ginard; Jan Kajstura; Annarosa Leri; Piero Anversa
Journal:  N Engl J Med       Date:  2002-01-03       Impact factor: 91.245

4.  Hepatocyte growth factor delivered by ultrasound-mediated destruction of microbubbles induces proliferation of cardiomyocytes and amelioration of left ventricular contractile function in Doxorubicin-induced cardiomyopathy.

Authors:  Masayoshi Iwasaki; Yasushi Adachi; Takashi Nishiue; Keizo Minamino; Yasuhiro Suzuki; Yuming Zhang; Keiji Nakano; Yasushi Koike; Jianfeng Wang; Hiromi Mukaide; Shigeru Taketani; Fumio Yuasa; Hirohito Tsubouchi; Eiichi Gohda; Toshiji Iwasaka; Susumu Ikehara
Journal:  Stem Cells       Date:  2005-08-18       Impact factor: 6.277

5.  Safety evaluation of clinical gene therapy using hepatocyte growth factor to treat peripheral arterial disease.

Authors:  Ryuichi Morishita; Motokuni Aoki; Naotaka Hashiya; Hirofumi Makino; Keita Yamasaki; Junya Azuma; Yoshiki Sawa; Hikaru Matsuda; Yasufumi Kaneda; Toshio Ogihara
Journal:  Hypertension       Date:  2004-07-06       Impact factor: 10.190

6.  Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells.

Authors:  Jalees Rehman; Dmitry Traktuev; Jingling Li; Stephanie Merfeld-Clauss; Constance J Temm-Grove; Jason E Bovenkerk; Carrie L Pell; Brian H Johnstone; Robert V Considine; Keith L March
Journal:  Circulation       Date:  2004-03-01       Impact factor: 29.690

7.  Phase I clinical trial on intracoronary administration of Ad-hHGF treating severe coronary artery disease.

Authors:  Zhi-Jian Yang; You-Rong Zhang; Bo Chen; Shu-Lan Zhang; En-Zhi Jia; Lian-Sheng Wang; Tie-Bing Zhu; Chun-Jian Li; Hui Wang; Jun Huang; Ke-Jiang Cao; Wen-Zhu Ma; Bin Wu; Li-Sheng Wang; Chu-Tse Wu
Journal:  Mol Biol Rep       Date:  2008-07-22       Impact factor: 2.316

8.  Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences.

Authors:  R Gum; E Lengyel; J Juarez; J H Chen; H Sato; M Seiki; D Boyd
Journal:  J Biol Chem       Date:  1996-05-03       Impact factor: 5.157

9.  Treatment with an adenoviral vector encoding hepatocyte growth factor mitigates established cardiac dysfunction in doxorubicin-induced cardiomyopathy.

Authors:  Masayasu Esaki; Genzou Takemura; Ken-ichiro Kosai; Tomoyuki Takahashi; Shusaku Miyata; Longhu Li; Kazuko Goto; Rumi Maruyama; Hideshi Okada; Hiromitsu Kanamori; Atsushi Ogino; Hiroaki Ushikoshi; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Journal:  Am J Physiol Heart Circ Physiol       Date:  2007-12-14       Impact factor: 4.733

10.  Effects of autologous bone marrow stem cell transplantation on beta-adrenoceptor density and electrical activation pattern in a rabbit model of non-ischemic heart failure.

Authors:  Stefan Dhein; Jens Garbade; Djazia Rouabah; Getu Abraham; Fritz-Rupert Ungemach; Katja Schneider; Cris Ullmann; Heike Aupperle; Jan Fritz Gummert; Friedrich-Wilhelm Mohr
Journal:  J Cardiothorac Surg       Date:  2006-06-26       Impact factor: 1.637
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  15 in total

1.  Role of c-Met/phosphatidylinositol 3-kinase (PI3k)/Akt signaling in hepatocyte growth factor (HGF)-mediated lamellipodia formation, reactive oxygen species (ROS) generation, and motility of lung endothelial cells.

Authors:  Peter V Usatyuk; Panfeng Fu; Vijay Mohan; Yulia Epshtein; Jeffrey R Jacobson; Julian Gomez-Cambronero; Kishore K Wary; Vytas Bindokas; Steven M Dudek; Ravi Salgia; Joe G N Garcia; Viswanathan Natarajan
Journal:  J Biol Chem       Date:  2014-03-14       Impact factor: 5.157

2.  Ad-HGF improves the cardiac remodeling of rat following myocardial infarction by upregulating autophagy and necroptosis and inhibiting apoptosis.

Authors:  Jiabao Liu; Peng Wu; Yunle Wang; Yingqiang Du; Nan A; Shuiyuan Liu; Yiming Zhang; Ningtian Zhou; Zhihui Xu; Zhijian Yang
Journal:  Am J Transl Res       Date:  2016-11-15       Impact factor: 4.060

Review 3.  A New Era of Cardiac Cell Therapy: Opportunities and Challenges.

Authors:  Ke Huang; Shiqi Hu; Ke Cheng
Journal:  Adv Healthc Mater       Date:  2018-12-13       Impact factor: 9.933

4.  A novel protein-engineered hepatocyte growth factor analog released via a shear-thinning injectable hydrogel enhances post-infarction ventricular function.

Authors:  Amanda N Steele; Lei Cai; Vi N Truong; Bryan B Edwards; Andrew B Goldstone; Anahita Eskandari; Aaron C Mitchell; Laura M Marquardt; Abbygail A Foster; Jennifer R Cochran; Sarah C Heilshorn; Y Joseph Woo
Journal:  Biotechnol Bioeng       Date:  2017-06-29       Impact factor: 4.530

Review 5.  MicroRNAs in myocardial ischemia: identifying new targets and tools for treating heart disease. New frontiers for miR-medicine.

Authors:  V Sala; S Bergerone; S Gatti; S Gallo; A Ponzetto; C Ponzetto; T Crepaldi
Journal:  Cell Mol Life Sci       Date:  2013-11-12       Impact factor: 9.261

6.  Gene expression profiling of HGF/Met activation in neonatal mouse heart.

Authors:  Stefano Gatti; Christian Leo; Simona Gallo; Valentina Sala; Enrico Bucci; Massimo Natale; Daniela Cantarella; Enzo Medico; Tiziana Crepaldi
Journal:  Transgenic Res       Date:  2012-12-06       Impact factor: 2.788

7.  Genomic responses during acute human anaphylaxis are characterized by upregulation of innate inflammatory gene networks.

Authors:  Shelley F Stone; Anthony Bosco; Anya Jones; Claire L Cotterell; Pauline E van Eeden; Glenn Arendts; Daniel M Fatovich; Simon G A Brown
Journal:  PLoS One       Date:  2014-07-01       Impact factor: 3.240

8.  Role of miR-128 in hypertension-induced myocardial injury.

Authors:  Jie Yin; Hongyan Liu; Lei Huan; Suping Song; Liying Han; Faxin Ren; Zengtang Zhang; Zhiqiang Zang; Junye Zhang; Shu Wang
Journal:  Exp Ther Med       Date:  2017-08-04       Impact factor: 2.447

Review 9.  Targeting pleiotropic signaling pathways to control adult cardiac stem cell fate and function.

Authors:  Stefania Pagliari; Jakub Jelinek; Gabriele Grassi; Giancarlo Forte
Journal:  Front Physiol       Date:  2014-07-01       Impact factor: 4.566

10.  Agonist antibodies activating the Met receptor protect cardiomyoblasts from cobalt chloride-induced apoptosis and autophagy.

Authors:  S Gallo; S Gatti; V Sala; R Albano; P Costelli; E Casanova; P M Comoglio; T Crepaldi
Journal:  Cell Death Dis       Date:  2014-04-17       Impact factor: 8.469
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