| Literature DB >> 21327910 |
Natig Gassanov1, Nasser Semmo2, Mariam Semmo3, Amir M Nia1, Uwe Fuhr4, Fikret Er5.
Abstract
Arginine vasopressin (AVP) is the major physiological regulator of renal water excretion and blood volume. The AVP pathways of V(1a)R-mediated vasoconstriction and V(2)R-induced water retention represent a potentially attractive target of therapy for edematous diseases. Experimental and clinical evidence suggests beneficial effects of AVP receptor antagonists by increasing free water excretion and serum sodium levels. This review provides an update on the therapeutic implication of newly developed AVP receptor antagonists in respective disorders, such as chronic heart failure, liver cirrhosis and syndrome of inappropriate antidiuretic hormone secretion.Entities:
Mesh:
Substances:
Year: 2011 PMID: 21327910 DOI: 10.1007/s00228-011-1006-7
Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN: 0031-6970 Impact factor: 2.953