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Literature DB >> 2132732

Genetic approaches to myofibril form and function in Drosophila.

Abstract

Myofibrils, the contractile organelles of muscle, are apt subjects for studies on the formation and function of actomyosin networks. Molecular genetic approaches are advancing our understanding of myofibril structure and assembly, and may offer a novel and useful approach for investigating the crossbridge cycle. We review recent progress in Drosophila.

Entities: Gene Species

Mesh：

Substances：
Muscle Proteins
Myosins

Year: 1990 PMID： 2132732 DOI： 10.1016/0168-9525(90)90127-r

Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639

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Cited

17 in total

1. Transgenic over-expression of a motor protein at high levels results in severe cardiac pathology.

Authors: J James; H Osinska; T E Hewett; T Kimball; R Klevitsky; S Witt; D G Hall; J Gulick; J Robbins
Journal: Transgenic Res Date: 1999-02 Impact factor: 2.788

2. Drosophila melanogaster paramyosin: developmental pattern, mapping and properties deduced from its complete coding sequence.

Authors: J Vinós; M Maroto; R Garesse; R Marco; M Cervera
Journal: Mol Gen Genet Date: 1992-02

Review 3. Invertebrate muscles: thin and thick filament structure; molecular basis of contraction and its regulation, catch and asynchronous muscle.

Authors: Scott L Hooper; Kevin H Hobbs; Jeffrey B Thuma
Journal: Prog Neurobiol Date: 2008-06-20 Impact factor: 11.685

4. Effects of calcium and nucleotides on the structure of insect flight muscle thin filaments.

Authors: T Ruiz; B Bullard; J Lepault
Journal: J Muscle Res Cell Motil Date: 1998-05 Impact factor: 2.698

5. The role of evolutionarily conserved sequences in alternative splicing at the 3' end of Drosophila melanogaster myosin heavy chain RNA.

Authors: D Hodges; R M Cripps; M E O'Connor; S I Bernstein
Journal: Genetics Date: 1999-01 Impact factor: 4.562

10. Alterations in flightin phosphorylation in Drosophila flight muscles are associated with myofibrillar defects engendered by actin and myosin heavy-chain mutant alleles.

Authors: J O Vigoreaux
Journal: Biochem Genet Date: 1994-08 Impact factor: 1.890

Genetic approaches to myofibril form and function in Drosophila.

1. Transgenic over-expression of a motor protein at high levels results in severe cardiac pathology.

2. Drosophila melanogaster paramyosin: developmental pattern, mapping and properties deduced from its complete coding sequence.

Review 3. Invertebrate muscles: thin and thick filament structure; molecular basis of contraction and its regulation, catch and asynchronous muscle.

4. Effects of calcium and nucleotides on the structure of insect flight muscle thin filaments.

5. The role of evolutionarily conserved sequences in alternative splicing at the 3' end of Drosophila melanogaster myosin heavy chain RNA.

6. Myosin heavy chain isoforms regulate muscle function but not myofibril assembly.

7. Small differences in Drosophila tropomyosin expression have significant effects on muscle function.

Review 8. Dynamic regulation of sarcomeric actin filaments in striated muscle.

9. A non-flight muscle isoform of Drosophila tropomyosin rescues an indirect flight muscle tropomyosin mutant.

10. Alterations in flightin phosphorylation in Drosophila flight muscles are associated with myofibrillar defects engendered by actin and myosin heavy-chain mutant alleles.