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Literature DB >> 21327156

Transcriptional regulation of the human telomerase reverse transcriptase: new insights.

Abstract

hTERT and NFAT were thought until recently to belong to separate metabolic compartments. The involvement of NFAT in the induction of hTERT transcription suggested by hTERT expression variations during lymphocyte stimulation and immunosuppressive treatments explains the link between hTERT expression and cell stimulation and offers new insights for therapeutic developments.

Entities: Gene Species

Keywords: NFAT; cell stimulation; hTERT; immunosuppression; tumorigenesis

Mesh：

Substances：

Year: 2010 PMID： 21327156 PMCID： PMC3035187 DOI： 10.4161/trns.1.1.12062

Source DB: PubMed Journal: Transcription ISSN： 2154-1272

34 in total

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Journal: Proc Natl Acad Sci U S A Date: 1999-04-27 Impact factor: 11.205

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Journal: Cancer Res Date: 1999-02-15 Impact factor: 12.701

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Journal: Nat Genet Date: 1998-06 Impact factor: 38.330

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Authors: E Smeland; T Godal; E Ruud; K Beiske; S Funderud; E A Clark; S Pfeifer-Ohlsson; R Ohlsson
Journal: Proc Natl Acad Sci U S A Date: 1985-09 Impact factor: 11.205

10. Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts.

Authors: G A Ulaner; J F Hu; T H Vu; L C Giudice; A R Hoffman
Journal: Cancer Res Date: 1998-09-15 Impact factor: 12.701

3 in total