L Salawu1, R A Bolarinwa, M A Durosinmi. 1. Department of Haematology & Blood Transfusion, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria. lsalawu2002@yahoo.co.uk
Abstract
AIM: To investigate the usefulness of some clinical and laboratory parameters in assessing the prognosis and survival of CLL in a resource-limited setting. METHODS: Between September 1986 and March 2007, 79 consecutive patients were retrospectively studied. Diagnosis was based on clinical and haematological findings. RESULTS: A total of 79 patients, aged 30 to 81 (median = 60) years were managed. There were 34 males and 45 females (ratio = 0.8:1). About 86.1% were aged above 50 years. Massive splenomegaly and hepatomegaly were recorded in 70.9% and 29.1% of patients, respectively. More than 63% presented in stage C. Anaemia was recorded in 74.7%. Haematocrit correlated negatively with WBC but positively with platelet count. The spleen correlated positively with liver. The overall survival at 2 years was 70.2%. Logistic regression showed that younger age, male sex, higher haematocrit, and lower platelet count improved survival, while lower WBC, moderate hepatomegaly and splenomegaly conferred survival advantage. CONCLUSION: It could be concluded that massive splenomegaly is a common finding in the majority of our patients. Non availability of immunophenotyping facility is a major constraint.
AIM: To investigate the usefulness of some clinical and laboratory parameters in assessing the prognosis and survival of CLL in a resource-limited setting. METHODS: Between September 1986 and March 2007, 79 consecutive patients were retrospectively studied. Diagnosis was based on clinical and haematological findings. RESULTS: A total of 79 patients, aged 30 to 81 (median = 60) years were managed. There were 34 males and 45 females (ratio = 0.8:1). About 86.1% were aged above 50 years. Massive splenomegaly and hepatomegaly were recorded in 70.9% and 29.1% of patients, respectively. More than 63% presented in stage C. Anaemia was recorded in 74.7%. Haematocrit correlated negatively with WBC but positively with platelet count. The spleen correlated positively with liver. The overall survival at 2 years was 70.2%. Logistic regression showed that younger age, male sex, higher haematocrit, and lower platelet count improved survival, while lower WBC, moderate hepatomegaly and splenomegaly conferred survival advantage. CONCLUSION: It could be concluded that massive splenomegaly is a common finding in the majority of our patients. Non availability of immunophenotyping facility is a major constraint.
Authors: J R de Faria; J S de Oliveira; R M Delbone de Faria; M R Silva; S Goihman; M Yamamoto; J Kerbauy Journal: Sao Paulo Med J Date: 2000-07-06 Impact factor: 1.044
Authors: Clive S Zent; Wei Ding; Susan M Schwager; Megan S Reinalda; James D Hoyer; Diane F Jelinek; Renee C Tschumper; Deborah A Bowen; Timothy G Call; Tait D Shanafelt; Neil E Kay; Susan L Slager Journal: Br J Haematol Date: 2008-03-27 Impact factor: 6.998
Authors: G De Rossi; L Granati; G Girelli; G Gandolo; P Perrone; M Martelli; L Conti; R Marini; D Pastorelli; S Coluzzi; P Niscola; F Pizzo; F Mandeli Journal: Tumori Date: 1991-04-30