BACKGROUND: The impact of the human immunodeficiency virus (HIV) infection on the respiratory system of Africans has been little studied. This study aimed to determine the pattern of respiratory symptoms and ventilatory functions in HIV infected Nigerians. METHODS: In this cross sectional study, Respiratory symptoms frequency, Forced vital capacity (FVC), Forced expiratory volume in one second (FEV(1)), FEV(1)/FVC ratio, Forced expiratory flow between 25% and 75% of FVC, were determined in 100 HIV positive subjects and compared with values in 100 HIV negative controls. RESULTS: HIV positive patients had significantly more respiratory symptoms and lower ventilatory function tests values compared to the matched controls (p<0.05). HIV patients with at least one respiratory symptom and those with CD4 count less than 200 cells/µl had lower ventilatory function values than their counterparts. 32% of the HIV patients had restrictive ventilatory functional impairment. (p<0.05). Using regression analysis, factors like HIV status, CD4 count and presence of respiratory symptoms were found to be associated with impairment in ventilatory functions. CONCLUSIONS: HIV infected patients had more frequent respiratory symptoms and lower ventilatory function values. Further lung function studies and CT scanning in HIV positive patients especially in those with respiratory symptoms are indicated.
BACKGROUND: The impact of the human immunodeficiency virus (HIV) infection on the respiratory system of Africans has been little studied. This study aimed to determine the pattern of respiratory symptoms and ventilatory functions in HIV infected Nigerians. METHODS: In this cross sectional study, Respiratory symptoms frequency, Forced vital capacity (FVC), Forced expiratory volume in one second (FEV(1)), FEV(1)/FVC ratio, Forced expiratory flow between 25% and 75% of FVC, were determined in 100 HIV positive subjects and compared with values in 100 HIV negative controls. RESULTS:HIV positive patients had significantly more respiratory symptoms and lower ventilatory function tests values compared to the matched controls (p<0.05). HIVpatients with at least one respiratory symptom and those with CD4 count less than 200 cells/µl had lower ventilatory function values than their counterparts. 32% of the HIVpatients had restrictive ventilatory functional impairment. (p<0.05). Using regression analysis, factors like HIV status, CD4 count and presence of respiratory symptoms were found to be associated with impairment in ventilatory functions. CONCLUSIONS:HIV infectedpatients had more frequent respiratory symptoms and lower ventilatory function values. Further lung function studies and CT scanning in HIV positive patients especially in those with respiratory symptoms are indicated.
Entities:
Keywords:
CD4; HIV; Nigeria; Respiratory symptom; ventilatory function
Authors: H L Twigg; D M Soliman; R B Day; K S Knox; R J Anderson; D S Wilkes; C T Schnizlein-Bick Journal: Am J Respir Crit Care Med Date: 1999-05 Impact factor: 21.405
Authors: D T McLeod; P Neill; V J Robertson; A S Latif; J C Emmanuel; J E Els; L K Gwanzura; F E Trijssenaar; P Nziramasanga; G R Jongeling Journal: Trans R Soc Trop Med Hyg Date: 1989 Sep-Oct Impact factor: 2.184
Authors: M J Rosen; Y Lou; P A Kvale; A V Rao; M C Jordan; A Miller; J Glassroth; L B Reichman; J M Wallace; P C Hopewell Journal: Am J Respir Crit Care Med Date: 1995-08 Impact factor: 21.405
Authors: Jessica A Kynyk; Jonathan P Parsons; Michael F Para; Susan L Koletar; Philip T Diaz; John G Mastronarde Journal: Respir Med Date: 2012-01-27 Impact factor: 3.415
Authors: Engi F Attia; Elizabeth Maleche-Obimbo; T Eoin West; Lilian Ndukwe-Wambutsi; Catherine Kiptinness; Anthony Cagle; Christine J McGrath; Celestine K Mugambi; Neveen G El Antouny; Sherry Eskander; Michael H Chung; Kristina Crothers Journal: AIDS Date: 2018-06-19 Impact factor: 4.177
Authors: Crystal M North; Linda Valeri; Peter W Hunt; A Rain Mocello; Jeffrey N Martin; Yap Boum; Jessica E Haberer; David R Bangsberg; David C Christiani; Mark J Siedner Journal: ERJ Open Res Date: 2017-05-18
Authors: Maren Kummerow; Erica J Shaddock; Kerstin Klipstein-Grobusch; Roos B Barth; Diederick E Grobbee; Francois D F Venter; Charles Feldman; Alinda Vos Journal: South Afr J HIV Med Date: 2019-09-26 Impact factor: 2.744
Authors: James Brown; Anjana Roy; Ross Harris; Sarah Filson; Margaret Johnson; Ibrahim Abubakar; Marc Lipman Journal: Thorax Date: 2016-10-24 Impact factor: 9.139