Literature DB >> 21326906

Genomic approaches for the discovery of CFTR regulatory elements.

Christopher J Ott1, Ann Harris.   

Abstract

Non-coding regions of the human genome contain vast regulatory potential that contributes to the coordination of gene expression. Indeed, regulatory elements can reside large genomic distances from the promoters of genes they control. Here we describe approaches recently used to identify functional elements within the complex CFTR locus.

Entities:  

Keywords:  CFTR; DNase I hypersensitivity; DNase-chip; chromosome conformation capture (3C); tissue-specific enhancers

Mesh：

Substances：

Year:  2011        PMID： 21326906      PMCID： PMC3023643          DOI： 10.4161/trns.2.1.13693

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  42 in total

1.  Genome-wide location and function of DNA binding proteins.

Authors:  B Ren; F Robert; J J Wyrick; O Aparicio; E G Jennings; I Simon; J Zeitlinger; J Schreiber; N Hannett; E Kanin; T L Volkert; C J Wilson; S P Bell; R A Young
Journal:  Science       Date:  2000-12-22       Impact factor: 47.728

2.  Multiple potential intragenic regulatory elements in the CFTR gene.

Authors:  D J Smith; H N Nuthall; M E Majetti; A Harris
Journal:  Genomics       Date:  2000-02-15       Impact factor: 5.736

3.  CFTR intron 1 increases luciferase expression driven by CFTR 5'-flanking DNA in a yeast artificial chromosome.

Authors:  P J Mogayzel; M A Ashlock
Journal:  Genomics       Date:  2000-03-01       Impact factor: 5.736

4.  An element in intron 1 of the CFTR gene augments intestinal expression in vivo.

Authors:  R K Rowntree; G Vassaux; T L McDowell; S Howe; A McGuigan; M Phylactides; C Huxley; A Harris
Journal:  Hum Mol Genet       Date:  2001-07-01       Impact factor: 6.150

5.  Capturing chromosome conformation.

Authors:  Job Dekker; Karsten Rippe; Martijn Dekker; Nancy Kleckner
Journal:  Science       Date:  2002-02-15       Impact factor: 47.728

6.  Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA.

Authors:  J R Riordan; J M Rommens; B Kerem; N Alon; R Rozmahel; Z Grzelczak; J Zielenski; S Lok; N Plavsic; J L Chou
Journal:  Science       Date:  1989-09-08       Impact factor: 47.728

7.  Analysis of a DNase I hypersensitive site located -20.9 kb upstream of the CFTR gene.

Authors:  H N Nuthall; G Vassaux; C Huxley; A Harris
Journal:  Eur J Biochem       Date:  1999-12

8.  Evaluation of potential regulatory elements identified as DNase I hypersensitive sites in the CFTR gene.

Authors:  Marios Phylactides; Rebecca Rowntree; Hugh Nuthall; David Ussery; Ann Wheeler; Ann Harris
Journal:  Eur J Biochem       Date:  2002-01

9.  HNF1alpha is involved in tissue-specific regulation of CFTR gene expression.

Authors:  Nathalie Mouchel; Sytse A Henstra; Victoria A McCarthy; Sarah H Williams; Marios Phylactides; Ann Harris
Journal:  Biochem J       Date:  2004-03-15       Impact factor: 3.857

10.  Position-independent, high-level expression of the human beta-globin gene in transgenic mice.

Authors:  F Grosveld; G B van Assendelft; D R Greaves; G Kollias
Journal:  Cell       Date:  1987-12-24       Impact factor: 41.582
View more
  4 in total

1.  MicroRNA regulation of expression of the cystic fibrosis transmembrane conductance regulator gene.

Authors:  Austin E Gillen; Nehal Gosalia; Shih-Hsing Leir; Ann Harris
Journal:  Biochem J       Date:  2011-08-15       Impact factor: 3.857

2.  Immune mediators regulate CFTR expression through a bifunctional airway-selective enhancer.

Authors:  Zhaolin Zhang; Shih-Hsing Leir; Ann Harris
Journal:  Mol Cell Biol       Date:  2013-05-20       Impact factor: 4.272

3.  Molecular mechanisms controlling CFTR gene expression in the airway.

Authors:  Zhaolin Zhang; Christopher J Ott; Marzena A Lewandowska; Shih-Hsing Leir; Ann Harris
Journal:  J Cell Mol Med       Date:  2012-06       Impact factor: 5.310

4.  Nucleosome occupancy reveals regulatory elements of the CFTR promoter.

Authors:  Christopher J Ott; Jared M Bischof; Kristen M Unti; Austin E Gillen; Shih-Hsing Leir; Ann Harris
Journal:  Nucleic Acids Res       Date:  2011-09-24       Impact factor: 16.971
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.