Literature DB >> 21326902

Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs.

Achim Leutz1, Ole Pless, Michael Lappe, Gunnar Dittmar, Elisabeth Kowenz-Leutz.   

Abstract

C/EBPs are implied in an amazing number of cellular functions: C/EBPs regulate tissue and cell type specific gene expression, proliferation, and differentiation control. C/EBPs assist in energy metabolism, female reproduction, innate immunity, inflammation, senescence, and the development of neoplasms. How can C/EBPs fulfill so many functions? Here we discuss that C/EBPs are extensively modified by methylation of arginine and lysine side chains and that regulated methylation profoundly affects the activity of C/EBPs.

Entities:  

Keywords:  chromatin remodeling; differentiation; histone code; methylation; post-translational modification; signaling; transcription

Mesh：

Substances：

Year:  2011        PMID： 21326902      PMCID： PMC3023639          DOI： 10.4161/trns.2.1.13510

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  48 in total

Review 1.  Translational control of gene expression and disease.

Authors:  Cornelis F Calkhoven; Christine Müller; Achim Leutz
Journal:  Trends Mol Med       Date:  2002-12       Impact factor: 11.951

2.  GlobPlot: Exploring protein sequences for globularity and disorder.

Authors:  Rune Linding; Robert B Russell; Victor Neduva; Toby J Gibson
Journal:  Nucleic Acids Res       Date:  2003-07-01       Impact factor: 16.971

Review 3.  Intrinsically unstructured proteins evolve by repeat expansion.

Authors:  Peter Tompa
Journal:  Bioessays       Date:  2003-09       Impact factor: 4.345

4.  When Ras signaling reaches the mediator.

Authors:  Dennis Eastburn; Min Han
Journal:  Dev Cell       Date:  2004-02       Impact factor: 12.270

5.  STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPbeta.

Authors:  Min Xu; Lei Nie; Seung-Hwan Kim; Xiao-Hong Sun
Journal:  EMBO J       Date:  2003-02-17       Impact factor: 11.598

6.  The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest.

Authors:  Christine Müller; Cornelis F Calkhoven; Xiaojing Sha; Achim Leutz
Journal:  J Biol Chem       Date:  2003-12-04       Impact factor: 5.157

7.  Ras induces mediator complex exchange on C/EBP beta.

Authors:  Xianming Mo; Elisabeth Kowenz-Leutz; Hong Xu; Achim Leutz
Journal:  Mol Cell       Date:  2004-01-30       Impact factor: 17.970

8.  A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3.

Authors:  Lalitha Subramanian; Mark D Benson; Jorge A Iñiguez-Lluhí
Journal:  J Biol Chem       Date:  2003-01-02       Impact factor: 5.157

9.  Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier (SUMO) family members, SUMO-2 and SUMO-3.

Authors:  Erin M Eaton; Linda Sealy
Journal:  J Biol Chem       Date:  2003-06-16       Impact factor: 5.157

10.  Transcriptional regulation of the cyclooxygenase-2 gene in macrophages by PU.1.

Authors:  Myungsoo Joo; Gye Young Park; Jeffrey G Wright; Timothy S Blackwell; Michael L Atchison; John W Christman
Journal:  J Biol Chem       Date:  2003-12-05       Impact factor: 5.157
View more
  9 in total

1.  A differential proteome screening system for post-translational modification-dependent transcription factor interactions.

Authors:  Ole Pless; Elisabeth Kowenz-Leutz; Gunnar Dittmar; Achim Leutz
Journal:  Nat Protoc       Date:  2011-02-24       Impact factor: 13.491

Review 2.  G9a, a multipotent regulator of gene expression.

Authors:  Shilpa Rani Shankar; Avinash G Bahirvani; Vinay Kumar Rao; Narendra Bharathy; Jin Rong Ow; Reshma Taneja
Journal:  Epigenetics       Date:  2012-12-20       Impact factor: 4.528

3.  Alternative splicing regulates the expression of G9A and SUV39H2 methyltransferases, and dramatically changes SUV39H2 functions.

Authors:  Oriane Mauger; Roscoe Klinck; Benoit Chabot; Christian Muchardt; Eric Allemand; Eric Batsché
Journal:  Nucleic Acids Res       Date:  2015-01-20       Impact factor: 16.971

4.  G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression.

Authors:  Xi Zhang; Danni Peng; Yuanxin Xi; Chao Yuan; Cari A Sagum; Brianna J Klein; Kaori Tanaka; Hong Wen; Tatiana G Kutateladze; Wei Li; Mark T Bedford; Xiaobing Shi
Journal:  Nat Commun       Date:  2016-03-10       Impact factor: 14.919

5.  PRISMA: Protein Interaction Screen on Peptide Matrix Reveals Interaction Footprints and Modifications- Dependent Interactome of Intrinsically Disordered C/EBPβ.

Authors:  Gunnar Dittmar; Daniel Perez Hernandez; Elisabeth Kowenz-Leutz; Marieluise Kirchner; Günther Kahlert; Radoslaw Wesolowski; Katharina Baum; Maria Knoblich; Maria Hofstätter; Arnaud Muller; Jana Wolf; Ulf Reimer; Achim Leutz
Journal:  iScience       Date:  2019-03-01

6.  Peptide array-based interactomics.

Authors:  Daniel Perez Hernandez; Gunnar Dittmar
Journal:  Anal Bioanal Chem       Date:  2021-05-03       Impact factor: 4.142

7.  PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

Authors:  Evelyn Ramberger; Valeria Sapozhnikova; Elisabeth Kowenz-Leutz; Karin Zimmermann; Nathalie Nicot; Petr V Nazarov; Daniel Perez-Hernandez; Ulf Reimer; Philipp Mertins; Gunnar Dittmar; Achim Leutz
Journal:  iScience       Date:  2021-06-04

8.  Lymphoid to myeloid cell trans-differentiation is determined by C/EBPβ structure and post-translational modifications.

Authors:  Bilyana Stoilova; Elisabeth Kowenz-Leutz; Marina Scheller; Achim Leutz
Journal:  PLoS One       Date:  2013-06-05       Impact factor: 3.240

9.  Systematic Analysis and Prediction of In Situ Cross Talk of O-GlcNAcylation and Phosphorylation.

Authors:  Heming Yao; Ao Li; Minghui Wang
Journal:  Biomed Res Int       Date:  2015-10-27       Impact factor: 3.411
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.