Literature DB >> 21326890

Non-redundant functions of the protein isoforms arising from alternative splicing of the VEGF-A pre-mRNA.

Mauro Giacca1.   

Abstract

The different protein isoforms generated from the vascular endothelial growth factor-A (VEGF-A) gene, an essential regulator of blood vessel formation, differ in biochemical property and functional activity. Despite the relevance of VEGF-A for both normal and pathologic angiogenesis, our understanding of the molecular mechanisms governing alternative splicing of its pre-mRNA is still in its infancy.

Entities:  

Year:  2010        PMID： 21326890      PMCID： PMC3023576          DOI： 10.4161/trns.1.3.13229

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  30 in total

1.  Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188.

Authors:  P Carmeliet; Y S Ng; D Nuyens; G Theilmeier; K Brusselmans; I Cornelissen; E Ehler; V V Kakkar; I Stalmans; V Mattot; J C Perriard; M Dewerchin; W Flameng; A Nagy; F Lupu; L Moons; D Collen; P A D'Amore; D T Shima
Journal:  Nat Med       Date:  1999-05       Impact factor: 53.440

2.  A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2.

Authors:  S Cébe Suarez; M Pieren; L Cariolato; S Arn; U Hoffmann; A Bogucki; C Manlius; J Wood; K Ballmer-Hofer
Journal:  Cell Mol Life Sci       Date:  2006-09       Impact factor: 9.261

3.  Vascular endothelial growth factor receptor-2 and neuropilin-1 form a receptor complex that is responsible for the differential signaling potency of VEGF(165) and VEGF(121).

Authors:  G B Whitaker; B J Limberg; J S Rosenbaum
Journal:  J Biol Chem       Date:  2001-05-01       Impact factor: 5.157

4.  Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor.

Authors:  S Soker; S Takashima; H Q Miao; G Neufeld; M Klagsbrun
Journal:  Cell       Date:  1998-03-20       Impact factor: 41.582

5.  The heparin-binding domain confers diverse functions of VEGF-A in development and disease: a structure-function study.

Authors:  Dominik Krilleke; Yin-Shan Eric Ng; David T Shima
Journal:  Biochem Soc Trans       Date:  2009-12       Impact factor: 5.407

6.  Inducible adeno-associated virus vectors promote functional angiogenesis in adult organisms via regulated vascular endothelial growth factor expression.

Authors:  Sabrina Tafuro; Eduard Ayuso; Serena Zacchigna; Lorena Zentilin; Silvia Moimas; Franca Dore; Mauro Giacca
Journal:  Cardiovasc Res       Date:  2009-05-14       Impact factor: 10.787

Review 7.  VEGF-A splicing: the key to anti-angiogenic therapeutics?

Authors:  Steven J Harper; David O Bates
Journal:  Nat Rev Cancer       Date:  2008-10-16       Impact factor: 60.716

8.  Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors.

Authors:  Dawid G Nowak; Jeanette Woolard; Elianna Mohamed Amin; Olga Konopatskaya; Moin A Saleem; Amanda J Churchill; Michael R Ladomery; Steven J Harper; David O Bates
Journal:  J Cell Sci       Date:  2008-10-15       Impact factor: 5.285

9.  Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression.

Authors:  L Miquerol; B L Langille; A Nagy
Journal:  Development       Date:  2000-09       Impact factor: 6.868

10.  Bone marrow mononuclear cells are recruited to the sites of VEGF-induced neovascularization but are not incorporated into the newly formed vessels.

Authors:  Lorena Zentilin; Sabrina Tafuro; Serena Zacchigna; Nikola Arsic; Lucia Pattarini; Milena Sinigaglia; Mauro Giacca
Journal:  Blood       Date:  2006-01-03       Impact factor: 22.113
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  7 in total

1.  VEGF-A and VEGF-B mRNA expression in gastro-oesophageal cancers.

Authors:  Cristina Angelescu; Florin Burada; Mihai Ioana; Radu Angelescu; Emil Moraru; Anca Riza; Sanda Marchian; Francisc Mixich; Mihai Cruce; Adrian Săftoiu
Journal:  Clin Transl Oncol       Date:  2012-08-08       Impact factor: 3.405

2.  Tissue deformation spatially modulates VEGF signaling and angiogenesis.

Authors:  Nicolas C Rivron; Erik J Vrij; Jeroen Rouwkema; Severine Le Gac; Albert van den Berg; Roman K Truckenmüller; Clemens A van Blitterswijk
Journal:  Proc Natl Acad Sci U S A       Date:  2012-04-17       Impact factor: 11.205

Review 3.  Vascular endothelial growth factor A: just one of multiple mechanisms for sex-specific vascular development within the testis?

Authors:  Kevin M Sargent; Renee M McFee; Renata Spuri Gomes; Andrea S Cupp
Journal:  J Endocrinol       Date:  2015-10-15       Impact factor: 4.286

4.  Abnormal histone methylation is responsible for increased vascular endothelial growth factor 165a secretion from airway smooth muscle cells in asthma.

Authors:  Rachel L Clifford; Alison E John; Christopher E Brightling; Alan J Knox
Journal:  J Immunol       Date:  2012-06-11       Impact factor: 5.422

5.  VEGF111b, a C-terminal splice variant of VEGF-A and induced by mitomycin C, inhibits ovarian cancer growth.

Authors:  Xiuli Li; Fang Gu; Chenguang Niu; Yuanfen Wang; Zhongyu Liu; Na Li; Bing Pan; Dan He; Jian Kong; Shaobo Zhang; Xu Wang; Yuanqing Yao; Lemin Zheng
Journal:  J Transl Med       Date:  2015-05-20       Impact factor: 5.531

Review 6.  New Insights into VEGF-A Alternative Splicing: Key Regulatory Switching in the Pathological Process.

Authors:  Fariba Dehghanian; Zohreh Hojati; Maryam Kay
Journal:  Avicenna J Med Biotechnol       Date:  2014-10

7.  An integrated regulatory network reveals pervasive cross-regulation among transcription and splicing factors.

Authors:  Idit Kosti; Predrag Radivojac; Yael Mandel-Gutfreund
Journal:  PLoS Comput Biol       Date:  2012-07-26       Impact factor: 4.475
  7 in total

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