| Literature DB >> 21326253 |
Jun-ya Ueda1, Miho Izumikawa, Akira Mukai, Aya Nagai, Ji-Hwan Hwang, Motoki Takagi, Kazuo Shin-ya.
Abstract
In the course of our screening program for anticancer agents from natural sources, five new angucyclines, JBIR-90 (1), -116 (2), -91 (3), -92 (4) and -93 (5), were isolated from the fermentation broth of Streptomyces sp. RI33. The structures of 1-5 were elucidated on the basis of 1D and 2D NMR spectroscopy and MS analyses. Compounds 2-4 showed cytotoxic activities against malignant pleural mesothelioma cells at IC(50) values of 20-50 μM.Entities:
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Year: 2011 PMID： 21326253 DOI： 10.1038/ja.2011.8
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649