David I Bernstein1. 1. Division of Immunology, Allergy and Rheumatology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. bernstdd@ucmail.uc.edu
Abstract
PURPOSE OF REVIEW: To discuss gene association studies conducted in workers diagnosed with occupational asthma. RECENT FINDINGS: Human leukocyte antigen studies conducted in European workers have defined major histocompatibility complex class II alleles and haplotypes associated with diisocyanate asthma. Recently, certain glutathione S-transferase genotypes (e.g. the GSTM1 null genotype) and N-acetyltransferase genotypes associated with slow acetylation phenotypes have been reported to be associated with diisocyanate asthma. Genotype combinations of IL-4 receptor-α and CD14 single nucleotide polymorphisms (SNPs) were significantly associated with diisocyanate asthma, but only in workers exposed to hexamethylene diisocyanate. A recent genome-wide association study (GWAS) conducted in Korea identified several SNPs of the α-T-catenin gene that were significantly associated with diisocyanate asthma. SUMMARY: Although candidate gene association studies have yet to identify reliable predictors of occupational asthma, future investigations including GWAS studies may identify high-risk genotypes allowing identification of workers at risk.
PURPOSE OF REVIEW: To discuss gene association studies conducted in workers diagnosed with occupational asthma. RECENT FINDINGS:Human leukocyte antigen studies conducted in European workers have defined major histocompatibility complex class II alleles and haplotypes associated with diisocyanateasthma. Recently, certain glutathione S-transferase genotypes (e.g. the GSTM1 null genotype) and N-acetyltransferase genotypes associated with slow acetylation phenotypes have been reported to be associated with diisocyanateasthma. Genotype combinations of IL-4 receptor-α and CD14 single nucleotide polymorphisms (SNPs) were significantly associated with diisocyanateasthma, but only in workers exposed to hexamethylene diisocyanate. A recent genome-wide association study (GWAS) conducted in Korea identified several SNPs of the α-T-catenin gene that were significantly associated with diisocyanateasthma. SUMMARY: Although candidate gene association studies have yet to identify reliable predictors of occupational asthma, future investigations including GWAS studies may identify high-risk genotypes allowing identification of workers at risk.
Authors: Jean-Luc Malo; Susan M Tarlo; Joaquin Sastre; James Martin; Mohamed F Jeebhay; Nicole Le Moual; Dick Heederik; Thomas Platts-Mills; Paul D Blanc; Olivier Vandenplas; Gianna Moscato; Frédéric de Blay; André Cartier Journal: Ann Am Thorac Soc Date: 2015-07
Authors: David I Bernstein; Michael Kashon; Zana L Lummus; Victor J Johnson; Kara Fluharty; Denyse Gautrin; Jean-Luc Malo; André Cartier; Louis-Philippe Boulet; Joaquin Sastre; Santiago Quirce; Dori Germolec; Susan M Tarlo; Maria-Jesus Cruz; Xavier Munoz; Michael I Luster; Berran Yucesoy Journal: Toxicol Sci Date: 2012-09-13 Impact factor: 4.849
Authors: Berran Yucesoy; Kenneth M Kaufman; Zana L Lummus; Matthew T Weirauch; Ge Zhang; André Cartier; Louis-Philippe Boulet; Joaquin Sastre; Santiago Quirce; Susan M Tarlo; Maria-Jesus Cruz; Xavier Munoz; John B Harley; David I Bernstein Journal: Toxicol Sci Date: 2015-04-26 Impact factor: 4.849
Authors: Bin Ouyang; David I Bernstein; Zana L Lummus; Jun Ying; Louis-Philippe Boulet; André Cartier; Denyse Gautrin; Shuk-Mei Ho Journal: Toxicol Sci Date: 2013-03-27 Impact factor: 4.849
Authors: Berran Yucesoy; Grace E Kissling; Victor J Johnson; Zana L Lummus; Denyse Gautrin; André Cartier; Louis-Philippe Boulet; Joaquin Sastre; Santiago Quirce; Susan M Tarlo; Maria-Jesus Cruz; Xavier Munoz; Michael I Luster; David I Bernstein Journal: J Occup Environ Med Date: 2015-12 Impact factor: 2.162