BACKGROUND/AIM: Bone loss in patients with osteoporosis may be predicted by the elevation of biochemical markers of bone turnover. Therefore, we studied the relationship between biochemical markers, including parathyroid hormone (PTH), and the 2-year change in radial cortical bone in patients under chronic hemodialysis. METHODS: Tartrate-resistant acid phosphatase-5b (TRACP-5b), bone-specific alkaline phosphatase, whole PTH, and total intact PTH were measured in 53 patients under maintenance hemodialysis. Additionally, radial cortical bone mineral density (BMD) and relative cortical area (RCA) were measured by peripheral quantitative computed tomography 2 years apart. RESULTS: In all patients, BMD decreased by 2.5% and RCA decreased by 5.8% during 2 years. TRACP-5b levels significantly correlated with decreased RCA in all and female patients, but not with decreased BMD. Bone-specific alkaline phosphatase correlated with decreased BMD in all patients and with decreased RCA in all and female patients. Whole PTH did not correlate with decreased RCA or BMD. Total intact PTH significantly correlated with decreased BMD in all and male patients and with decreased RCA in all and female patients. In stepwise multiple regression analysis, TRACP-5b and total intact PTH were selected as explanatory variables for decreased RCA and decreased BMD, respectively. CONCLUSION: These results suggest that TRACP-5b and total intact PTH are powerful markers to predict radial cortical bone loss in hemodialysis patients.
BACKGROUND/AIM: Bone loss in patients with osteoporosis may be predicted by the elevation of biochemical markers of bone turnover. Therefore, we studied the relationship between biochemical markers, including parathyroid hormone (PTH), and the 2-year change in radial cortical bone in patients under chronic hemodialysis. METHODS:Tartrate-resistant acid phosphatase-5b (TRACP-5b), bone-specific alkaline phosphatase, whole PTH, and total intact PTH were measured in 53 patients under maintenance hemodialysis. Additionally, radial cortical bone mineral density (BMD) and relative cortical area (RCA) were measured by peripheral quantitative computed tomography 2 years apart. RESULTS: In all patients, BMD decreased by 2.5% and RCA decreased by 5.8% during 2 years. TRACP-5b levels significantly correlated with decreased RCA in all and female patients, but not with decreased BMD. Bone-specific alkaline phosphatase correlated with decreased BMD in all patients and with decreased RCA in all and female patients. Whole PTH did not correlate with decreased RCA or BMD. Total intact PTH significantly correlated with decreased BMD in all and male patients and with decreased RCA in all and female patients. In stepwise multiple regression analysis, TRACP-5b and total intact PTH were selected as explanatory variables for decreased RCA and decreased BMD, respectively. CONCLUSION: These results suggest that TRACP-5b and total intact PTH are powerful markers to predict radial cortical bone loss in hemodialysis patients.
Authors: Oliver Malle; Markus Bergthaler; Peter Krisper; Karin Amrein; Hans Peter Dimai; Alexander H Kirsch; Alexander R Rosenkranz; Thomas Pieber; Barbara Obermayer-Pietsch; Astrid Fahrleitner-Pammer Journal: Wien Klin Wochenschr Date: 2022-03-09 Impact factor: 2.275
Authors: Adrian Covic; Jutta Passlick-Deetjen; Miroslaw Kroczak; Beatrix Büschges-Seraphin; Adrian Ghenu; Pedro Ponce; Barbara Marzell; Angel L M de Francisco Journal: Nephrol Dial Transplant Date: 2013-06-19 Impact factor: 5.992
Authors: Anne Tsampalieros; Heidi J Kalkwarf; Rachel J Wetzsteon; Justine Shults; Babette S Zemel; Bethany J Foster; Debbie L Foerster; Mary B Leonard Journal: Kidney Int Date: 2012-10-03 Impact factor: 10.612