BACKGROUND: Oxidative stress has been linked to the progression of disease, including chronic kidney disease (CKD). The aim of the present study was to determine the association between single-nucleotide polymorphisms (SNPs) of the antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase and their activities and the progression of CKD. METHODS: This is a prospective cohort study of 185 CKD patients (Stages 2-4), followed for up to 12 months. All patients were genotyped for SNPs of SOD (SOD Ala16Val), GPx (GPx Pro197Leu) and catalase (C-262T). The rate of change over the study period of estimated glomerular filtration rate (eGFR), plasma and red blood cell (RBC) GPx, RBC SOD and RBC catalase activities were determined. RESULTS: CKD patients with the SOD Ala/Val and Val/Val genotypes had a significantly greater eGFR decline compared to those with the Ala/Ala genotype (Ala/Val compared with Ala/Ala odds ratio (OR) 0.35, 95% CI 0.19 to 0.64, P = 0.001; Val/Val compared with Ala/Ala OR 0.25, 95% CI 0.10 to 0.65, P = 0.005). The progression of CKD was not associated with SNPs of the GPx or catalase genes studied but there was a direct relationship between the rate of change of plasma GPx activity and the rate of change of eGFR over 12 months (P = 0.025). CONCLUSION: CKD patients with the SOD Ala/Val and Val/Val genotypes have a greater decline in kidney function than those with the Ala/Ala genotype.
BACKGROUND: Oxidative stress has been linked to the progression of disease, including chronic kidney disease (CKD). The aim of the present study was to determine the association between single-nucleotide polymorphisms (SNPs) of the antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase and their activities and the progression of CKD. METHODS: This is a prospective cohort study of 185 CKDpatients (Stages 2-4), followed for up to 12 months. All patients were genotyped for SNPs of SOD (SODAla16Val), GPx (GPx Pro197Leu) and catalase (C-262T). The rate of change over the study period of estimated glomerular filtration rate (eGFR), plasma and red blood cell (RBC) GPx, RBC SOD and RBC catalase activities were determined. RESULTS:CKDpatients with the SODAla/Val and Val/Val genotypes had a significantly greater eGFR decline compared to those with the Ala/Ala genotype (Ala/Val compared with Ala/Ala odds ratio (OR) 0.35, 95% CI 0.19 to 0.64, P = 0.001; Val/Val compared with Ala/Ala OR 0.25, 95% CI 0.10 to 0.65, P = 0.005). The progression of CKD was not associated with SNPs of the GPx or catalase genes studied but there was a direct relationship between the rate of change of plasma GPx activity and the rate of change of eGFR over 12 months (P = 0.025). CONCLUSION:CKDpatients with the SODAla/Val and Val/Val genotypes have a greater decline in kidney function than those with the Ala/Ala genotype.
Authors: Marco Aurélio Almeida de Oliveira; Neila Hiraishi Mallmann; Giselle Katiane Bonfim Bacellar de Souza; Thiago de Jesus Bacha; Emerson Silva Lima; Domingos Sávio Nunes de Lima; Luiz Fernando de Souza Passos; Marilda de Souza Gonçalves; José Pereira de Moura Neto Journal: Clin Rheumatol Date: 2021-03-20 Impact factor: 2.980
Authors: Karl A Rodriguez; Ewa Wywial; Viviana I Perez; Adriant J Lambert; Yael H Edrey; Kaitlyn N Lewis; Kelly Grimes; Merry L Lindsey; Martin D Brand; Rochelle Buffenstein Journal: Curr Pharm Des Date: 2011 Impact factor: 3.116
Authors: David M Small; Kassia S Beetham; Erin J Howden; David R Briskey; David W Johnson; Nicole M Isbel; Glenda C Gobe; Jeff S Coombes Journal: Redox Rep Date: 2017-01-11 Impact factor: 4.412
Authors: Mohamed S El-Shimi; Rania A El-Farrash; Eman A Ismail; Ibrahim A El-Safty; A El-Safty; Ahmed S Nada; Omayma A El-Gamel; Yomna M Salem; Sara M Shoukry Journal: Pediatr Nephrol Date: 2015-05-16 Impact factor: 3.714