Literature DB >> 21325132

JNK regulates FoxO-dependent autophagy in neurons.

Ping Xu1, Madhumita Das, Judith Reilly, Roger J Davis.   

Abstract

The cJun N-terminal kinase (JNK) signal transduction pathway is implicated in the regulation of neuronal function. JNK is encoded by three genes that play partially redundant roles. Here we report the creation of mice with targeted ablation of all three Jnk genes in neurons. Compound JNK-deficient neurons are dependent on autophagy for survival. This autophagic response is caused by FoxO-induced expression of Bnip3 that displaces the autophagic effector Beclin-1 from inactive Bcl-XL complexes. These data identify JNK as a potent negative regulator of FoxO-dependent autophagy in neurons.

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Year:  2011        PMID： 21325132      PMCID： PMC3042155          DOI： 10.1101/gad.1984311

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  77 in total

1.  Rap2-JNK removes synaptic AMPA receptors during depotentiation.

Authors:  Yinghua Zhu; Daniel Pak; Yi Qin; Stefanie G McCormack; Myung J Kim; Joel P Baumgart; Vanisree Velamoor; Yves P Auberson; Pavel Osten; Linda van Aelst; Morgan Sheng; J Julius Zhu
Journal:  Neuron       Date:  2005-06-16       Impact factor: 17.173

2.  Loss of autophagy in the central nervous system causes neurodegeneration in mice.

Authors:  Masaaki Komatsu; Satoshi Waguri; Tomoki Chiba; Shigeo Murata; Jun-ichi Iwata; Isei Tanida; Takashi Ueno; Masato Koike; Yasuo Uchiyama; Eiki Kominami; Keiji Tanaka
Journal:  Nature       Date:  2006-04-19       Impact factor: 49.962

3.  Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice.

Authors:  Taichi Hara; Kenji Nakamura; Makoto Matsui; Akitsugu Yamamoto; Yohko Nakahara; Rika Suzuki-Migishima; Minesuke Yokoyama; Kenji Mishima; Ichiro Saito; Hideyuki Okano; Noboru Mizushima
Journal:  Nature       Date:  2006-04-19       Impact factor: 49.962

4.  Impaired long-term potentiation in c-Jun N-terminal kinase 2-deficient mice.

Authors:  Ju-Tao Chen; Da-Hua Lu; Chern-Pang Chia; Di-Yun Ruan; Kanaga Sabapathy; Zhi-Cheng Xiao
Journal:  J Neurochem       Date:  2005-04       Impact factor: 5.372

Review 5.  FoxO transcription factors in the maintenance of cellular homeostasis during aging.

Authors:  Dervis A M Salih; Anne Brunet
Journal:  Curr Opin Cell Biol       Date:  2008-04-03       Impact factor: 8.382

Review 6.  The bright side of JNKs-Multitalented mediators in neuronal sprouting, brain development and nerve fiber regeneration.

Authors:  Vicki Waetzig; Yi Zhao; Thomas Herdegen
Journal:  Prog Neurobiol       Date:  2006-10-11       Impact factor: 11.685

7.  Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector.

Authors:  Benny Björkblom; Nina Ostman; Vesa Hongisto; Vladislav Komarovski; Jan-Jonas Filén; Tuula A Nyman; Tuula Kallunki; Michael J Courtney; Eleanor T Coffey
Journal:  J Neurosci       Date:  2005-07-06       Impact factor: 6.167

Review 8.  Context-specific inhibition of JNKs: overcoming the dilemma of protection and damage.

Authors:  Vicki Waetzig; Thomas Herdegen
Journal:  Trends Pharmacol Sci       Date:  2005-09       Impact factor: 14.819

9.  JNK2 is a positive regulator of the cJun transcription factor.

Authors:  Anja Jaeschke; Maria Karasarides; Juan-Jose Ventura; Anka Ehrhardt; Chao Zhang; Richard A Flavell; Kevan M Shokat; Roger J Davis
Journal:  Mol Cell       Date:  2006-09-15       Impact factor: 17.970

10.  JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length.

Authors:  Tatsiana Tararuk; Nina Ostman; Wenrui Li; Benny Björkblom; Artur Padzik; Justyna Zdrojewska; Vesa Hongisto; Thomas Herdegen; Witold Konopka; Michael J Courtney; Eleanor T Coffey
Journal:  J Cell Biol       Date:  2006-04-17       Impact factor: 10.539
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  116 in total

1.  Whole genome expression profile in neuroblastoma cells exposed to 1-methyl-4-phenylpyridine.

Authors:  E Mazzio; K F A Soliman
Journal:  Neurotoxicology       Date:  2012-07-07       Impact factor: 4.294

2.  ER stress: Autophagy induction, inhibition and selection.

Authors:  Harun-Or Rashid; Raj Kumar Yadav; Hyung-Ryong Kim; Han-Jung Chae
Journal:  Autophagy       Date:  2015-11-02       Impact factor: 16.016

Review 3.  The return of the nucleus: transcriptional and epigenetic control of autophagy.

Authors:  Jens Füllgrabe; Daniel J Klionsky; Bertrand Joseph
Journal:  Nat Rev Mol Cell Biol       Date:  2013-12-11       Impact factor: 94.444

Review 4.  Autophagy: regulation and role in development.

Authors:  Amber N Hale; Dan J Ledbetter; Thomas R Gawriluk; Edmund B Rucker
Journal:  Autophagy       Date:  2013-07       Impact factor: 16.016

5.  Getting the better of ER stress.

Authors:  Bertrand Mollereau; Serge Manié; Francesco Napoletano
Journal:  J Cell Commun Signal       Date:  2014-10-30       Impact factor: 5.782

Review 6.  FOXO in Neural Cells and Diseases of the Nervous System.

Authors:  Evan E Santo; Jihye Paik
Journal:  Curr Top Dev Biol       Date:  2018-02-03       Impact factor: 4.897

Review 7.  Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress.

Authors:  Shane Deegan; Svetlana Saveljeva; Adrienne M Gorman; Afshin Samali
Journal:  Cell Mol Life Sci       Date:  2012-09-28       Impact factor: 9.261

8.  c-Jun N-Terminal Kinases (JNKs) Are Critical Mediators of Osteoblast Activity In Vivo.

Authors:  Ren Xu; Chao Zhang; Dong Yeon Shin; Jung-Min Kim; Sarfaraz Lalani; Na Li; Yeon-Suk Yang; Yifang Liu; Mark Eiseman; Roger J Davis; Jae-Hyuck Shim; Matthew B Greenblatt
Journal:  J Bone Miner Res       Date:  2017-09       Impact factor: 6.741

9.  Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy.

Authors:  Virginia Hernández-Gea; Moira Hilscher; Raphael Rozenfeld; Maribel P Lim; Natalia Nieto; Sabine Werner; Lakshmi A Devi; Scott L Friedman
Journal:  J Hepatol       Date:  2013-02-26       Impact factor: 25.083

10.  Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway.

Authors:  Shi-Hao Tan; Guanghou Shui; Jing Zhou; Yin Shi; Jingxiang Huang; Dajing Xia; Markus R Wenk; Han-Ming Shen
Journal:  Autophagy       Date:  2013-11-26       Impact factor: 16.016
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