BACKGROUND: There is at present a relative lack of knowledge concerning drug-related colitides, although these may be not infrequent entities in clinical practice. AIMS: To assess the frequency and the clinical-pathological subtypes of drug-related colitides in a gastrointestinal pathology referral centre. METHODS: All charts of endoscopic biopsy samples referred for colitis in a eight-year period were reviewed. To be classified as drug related colitis, patients' charts should report the use of any drug in a two month period before colonoscopy and no other obvious cases of colitis be present. For analysis, we considered only patients taking one drug in this period. RESULTS: We found 122 cases of drug-related colitis out of 3877 charts reviewed (3% of the overall colitis group). These cases were represented by microscopic colitis (50%), eosinophil rich infiltrate of the left colon (34%), ischemic colitis (11%), pseudomembranous colitis (3%), apoptotic colopathy (2%). The drugs most frequently associated with these colitides were represented by non-steroidal anti-inflammatory drugs. CONCLUSION: It is important to raise awareness concerning drug-related colitides, to avoid diagnostic errors and provide a better therapeutic approach to patients with these conditions.
BACKGROUND: There is at present a relative lack of knowledge concerning drug-related colitides, although these may be not infrequent entities in clinical practice. AIMS: To assess the frequency and the clinical-pathological subtypes of drug-related colitides in a gastrointestinal pathology referral centre. METHODS: All charts of endoscopic biopsy samples referred for colitis in a eight-year period were reviewed. To be classified as drug related colitis, patients' charts should report the use of any drug in a two month period before colonoscopy and no other obvious cases of colitis be present. For analysis, we considered only patients taking one drug in this period. RESULTS: We found 122 cases of drug-related colitis out of 3877 charts reviewed (3% of the overall colitis group). These cases were represented by microscopic colitis (50%), eosinophil rich infiltrate of the left colon (34%), ischemic colitis (11%), pseudomembranous colitis (3%), apoptotic colopathy (2%). The drugs most frequently associated with these colitides were represented by non-steroidal anti-inflammatory drugs. CONCLUSION: It is important to raise awareness concerning drug-related colitides, to avoid diagnostic errors and provide a better therapeutic approach to patients with these conditions.
Authors: Muhammad Bader Hammami; Ahmad Al-Taee; Marshall Meeks; Mark Fesler; M Yadira Hurley; Dengfeng Cao; Jin-Ping Lai Journal: Clin J Gastroenterol Date: 2016-12-26
Authors: Maria Pina Dore; Vincenzo Villanacci; Alessandra Manca; Sara Soro; Marco Schiavo-Lena; Giuseppe Sabatino; David Yates Graham; Gabrio Bassotti Journal: Intern Emerg Med Date: 2013-03-15 Impact factor: 3.397
Authors: Damian Maseda; Joseph P Zackular; Bruno Trindade; Leslie Kirk; Jennifer Lising Roxas; Lisa M Rogers; Mary K Washington; Liping Du; Tatsuki Koyama; V K Viswanathan; Gayatri Vedantam; Patrick D Schloss; Leslie J Crofford; Eric P Skaar; David M Aronoff Journal: mBio Date: 2019-01-08 Impact factor: 7.867