| Literature DB >> 21324685 |
Lianhong Xu1, Lijun Zhang, Robert Jones, Clifford Bryant, Nina Boddeker, Eric Mabery, Gina Bahador, Julia Watson, Jeffery Clough, Murty Arimilli, Wendy Gillette, Dorothy Colagiovanni, Keyu Wang, Craig Gibbs, Choung U Kim.
Abstract
There is an urgent need for the development of novel antimicrobial agents that offer effective treatment against MRSA. Using a new class of dipeptide antibiotic TAN-1057A/B as lead, we designed, synthesized and evaluated analogs of TAN-1057A/B. Several novel dihydropyrimidinone antibiotics demonstrating comparable antibiotic efficacy while possessing favorable selectivity were identified.Entities:
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Year: 2011 PMID： 21324685 DOI： 10.1016/j.bmcl.2011.01.099
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823