Shaji K Chacko1, Jorge Ordonez, Pieter J J Sauer, Agneta L Sunehag. 1. US Department of Agriculture Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Abstract
OBJECTIVE: To determine potential factors regulating gluconeogenesis (GNG) in extremely low birth weight infants receiving total parenteral nutrition. STUDY DESIGN: Seven infants (birth weight, 0.824 ± 0.068 kg; gestational age, 25.4 ± 0.5 weeks; postnatal age, 3.3 ± 0.2 days) were studied for 11 hours, with parenteral lipid and amino acid therapy continued at prestudy rates. Glucose was supplied at prestudy rates for the first 5 hours (period 1) and was then reduced to 6 mg/kg·min for 1 hour and further to ~3 mg/kg·min for 5 hours (period 2). A total of 2.5 mg/kg·min of the glucose was replaced by [U-(13)C]glucose throughout the study for measurements of glucose production and GNG. Concentrations of glucose, insulin, glucagons, and cortisol were determined. RESULTS: GNG and glucose production remained unchanged (2.12 ± 0.23 vs. 1.84 ± 0.25 mg/kg·min [P = NS] and 2.44 ± 0.27 vs. 2.51 ± 0.31 mg/kg·min [P = NS], respectively), despite a 60% reduction of the glucose infusion rate and subsequent 30% (124.7 ± 10.8 to 82.6 ± 8.9 mg/dL; P = .009) and 70% (26.9 ± 4.7 to 6.6 ± 0.4 μU/mL; P = .002) decreases in glucose and insulin concentrations, respectively. Cortisol and glucagon concentrations remained unchanged. CONCLUSION: In extremely low birth weight infants receiving total parenteral nutrition, GNG is a continuous process that is not affected by infusion rates of glucose or concentrations of glucose or insulin.
OBJECTIVE: To determine potential factors regulating gluconeogenesis (GNG) in extremely low birth weightinfants receiving total parenteral nutrition. STUDY DESIGN: Seven infants (birth weight, 0.824 ± 0.068 kg; gestational age, 25.4 ± 0.5 weeks; postnatal age, 3.3 ± 0.2 days) were studied for 11 hours, with parenteral lipid and amino acid therapy continued at prestudy rates. Glucose was supplied at prestudy rates for the first 5 hours (period 1) and was then reduced to 6 mg/kg·min for 1 hour and further to ~3 mg/kg·min for 5 hours (period 2). A total of 2.5 mg/kg·min of the glucose was replaced by [U-(13)C]glucose throughout the study for measurements of glucose production and GNG. Concentrations of glucose, insulin, glucagons, and cortisol were determined. RESULTS: GNG and glucose production remained unchanged (2.12 ± 0.23 vs. 1.84 ± 0.25 mg/kg·min [P = NS] and 2.44 ± 0.27 vs. 2.51 ± 0.31 mg/kg·min [P = NS], respectively), despite a 60% reduction of the glucose infusion rate and subsequent 30% (124.7 ± 10.8 to 82.6 ± 8.9 mg/dL; P = .009) and 70% (26.9 ± 4.7 to 6.6 ± 0.4 μU/mL; P = .002) decreases in glucose and insulin concentrations, respectively. Cortisol and glucagon concentrations remained unchanged. CONCLUSION: In extremely low birth weightinfants receiving total parenteral nutrition, GNG is a continuous process that is not affected by infusion rates of glucose or concentrations of glucose or insulin.
Authors: Agneta L Sunehag; Gianna Toffolo; Marco Campioni; Dennis M Bier; Morey W Haymond Journal: J Clin Endocrinol Metab Date: 2005-05-31 Impact factor: 5.958
Authors: Lesley Jackson; Fiona L R Williams; Ann Burchell; Michael W H Coughtrie; Robert Hume Journal: J Clin Endocrinol Metab Date: 2004-12 Impact factor: 5.958
Authors: Kathryn Beardsall; Sophie Vanhaesebrouck; Amanda L Ogilvy-Stuart; Christine Vanhole; Christopher R Palmer; Mirjam van Weissenbruch; Paula Midgley; Michael Thompson; Marta Thio; Luc Cornette; Iviano Ossuetta; Isabel Iglesias; Claire Theyskens; Miranda de Jong; Jag S Ahluwalia; Francis de Zegher; David B Dunger Journal: N Engl J Med Date: 2008-10-30 Impact factor: 91.245
Authors: Stephanie R Thorn; Satya M Sekar; Jinny R Lavezzi; Meghan C O'Meara; Laura D Brown; William W Hay; Paul J Rozance Journal: Am J Physiol Regul Integr Comp Physiol Date: 2012-08-29 Impact factor: 3.619
Authors: Jennifer L Dickson; James N Hewett; Cameron A Gunn; Adrienne Lynn; Geoffrey M Shaw; J Geoffrey Chase Journal: J Diabetes Sci Technol Date: 2013-07-01