Literature DB >> 21324238

How does electroconvulsive therapy work? Theories on its mechanism.

Tom G Bolwig1.   

Abstract

This article reviews 3 current theories of electroconvulsive therapy (ECT). One theory points to generalized seizures as essential for the therapeutic efficacy of ECT. Another theory highlights the normalization of neuroendocrine dysfunction in melancholic depression as a result of ECT. A third theory is based on recent findings of increased hippocampal neurogenesis and synaptogenesis in experimental animals given electroconvulsive seizures. Presently, the endocrine theory has the strongest foundation to explain the working mechanism of ECT.

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Year:  2011        PMID： 21324238     DOI： 10.1177/070674371105600104

Source DB:  PubMed          Journal:  Can J Psychiatry        ISSN： 0706-7437            Impact factor:   4.356


  25 in total

Review 1.  Fundamentals of transcranial electric and magnetic stimulation dose: definition, selection, and reporting practices.

Authors:  Angel V Peterchev; Timothy A Wagner; Pedro C Miranda; Michael A Nitsche; Walter Paulus; Sarah H Lisanby; Alvaro Pascual-Leone; Marom Bikson
Journal:  Brain Stimul       Date:  2011-11-01       Impact factor: 8.955

Review 2.  Neuromodulation for treatment-refractory major depressive disorder.

Authors:  Nir Lipsman; Tejas Sankar; Jonathan Downar; Sidney H Kennedy; Andres M Lozano; Peter Giacobbe
Journal:  CMAJ       Date:  2013-07-29       Impact factor: 8.262

3.  Relationship Between Hippocampal Volume, Serum BDNF, and Depression Severity Following Electroconvulsive Therapy in Late-Life Depression.

Authors:  Filip Bouckaert; Annemiek Dols; Louise Emsell; François-Laurent De Winter; Kristof Vansteelandt; Lene Claes; Stefan Sunaert; Max Stek; Pascal Sienaert; Mathieu Vandenbulcke
Journal:  Neuropsychopharmacology       Date:  2016-06-08       Impact factor: 7.853

4.  Alteration of immune markers in a group of melancholic depressed patients and their response to electroconvulsive therapy.

Authors:  Gavin Rush; Aoife O'Donovan; Laura Nagle; Catherine Conway; AnnMaria McCrohan; Cliona O'Farrelly; James V Lucey; Kevin M Malone
Journal:  J Affect Disord       Date:  2016-06-17       Impact factor: 4.839

5.  Modulation of intrinsic brain activity by electroconvulsive therapy in major depression.

Authors:  Amber M Leaver; Randall Espinoza; Tara Pirnia; Shantanu H Joshi; Roger P Woods; Katherine L Narr
Journal:  Biol Psychiatry Cogn Neurosci Neuroimaging       Date:  2016-01

6.  Electroconvulsive therapy: a novel hypothesis for the involvement of purinergic signalling.

Authors:  Ahmed-Ramadan Sadek; Gillian E Knight; Geoffrey Burnstock
Journal:  Purinergic Signal       Date:  2011-06-22       Impact factor: 3.765

7.  General Anaesthesia Protocols for Patients Undergoing Electroconvulsive Therapy: Retrospective analysis of 504 sessions over a five-year period at a tertiary care hospital in Oman.

Authors:  Aravind Narayanan; Chandar Lal; Hamed Al-Sinawi
Journal:  Sultan Qaboos Univ Med J       Date:  2017-03-30

8.  A functional MRI marker may predict the outcome of electroconvulsive therapy in severe and treatment-resistant depression.

Authors:  J A van Waarde; H S Scholte; L J B van Oudheusden; B Verwey; D Denys; G A van Wingen
Journal:  Mol Psychiatry       Date:  2014-08-05       Impact factor: 15.992

9.  Hippocampal volume and total cell numbers in major depressive disorder.

Authors:  Justin A Cobb; Joy Simpson; Gouri J Mahajan; James C Overholser; George J Jurjus; Lesa Dieter; Nicole Herbst; Warren May; Grazyna Rajkowska; Craig A Stockmeier
Journal:  J Psychiatr Res       Date:  2012-11-30       Impact factor: 4.791

10.  Complete cognitive recovery in a severe case of anti-N-methyl-d-aspartate receptor encephalitis treated with electroconvulsive therapy.

Authors:  Cæcilie Leding; Lisbet Marstrand; Anders Jorgensen
Journal:  BMJ Case Rep       Date:  2020-02-06
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