Jie Song1, Hui Li, Xiao-dong Zhang. 1. Blood Refreshment Center of Nephrosis Department, Hospital Affiliated with Armed Police Medical School, Tianjin, China. Songjie-7808@163.com
Abstract
AIM: To study the influence of different blood purification technology on plasma leptin and neuropeptide Y (NPY). METHODS: 150 patients with chronic renal failure in our hospital were included, which were divided into hemodialysis (HD) group, hemoperfusion (HP) group, and hemofiltration (HF) group. The serum leptin and neuropeptide Y levels were measured by radioimmunoassay (RIA) before and after first treatment, after treatment for 3, 6 month. RESULTS: Serum leptin and NPY were significantly lower after HDF and HP (P < 0.05), but not after HD in single treatment and for 3, 6 months treatment (P > 0.05). Serum leptin and NPY in group HDF and HP patients in single treatment and for 3, 6 months treatment were significantly greater than those of group HD (P < 0.05). The clearance rate of leptin and NPY in group HDF and HP patients were significantly greater than those of group HD (P < 0.05). There is no correlation between serum leptin and NPY (P > 0.05). CONCLUSION: Hemodialysis can not lower serum leptin and NPY. But HDF and HP can eliminate serum leptin and NPY preferably, which may improve the patients' nutritional status.
AIM: To study the influence of different blood purification technology on plasma leptin and neuropeptide Y (NPY). METHODS: 150 patients with chronic renal failure in our hospital were included, which were divided into hemodialysis (HD) group, hemoperfusion (HP) group, and hemofiltration (HF) group. The serum leptin and neuropeptide Y levels were measured by radioimmunoassay (RIA) before and after first treatment, after treatment for 3, 6 month. RESULTS: Serum leptin and NPY were significantly lower after HDF and HP (P < 0.05), but not after HD in single treatment and for 3, 6 months treatment (P > 0.05). Serum leptin and NPY in group HDF and HP patients in single treatment and for 3, 6 months treatment were significantly greater than those of group HD (P < 0.05). The clearance rate of leptin and NPY in group HDF and HP patients were significantly greater than those of group HD (P < 0.05). There is no correlation between serum leptin and NPY (P > 0.05). CONCLUSION: Hemodialysis can not lower serum leptin and NPY. But HDF and HP can eliminate serum leptin and NPY preferably, which may improve the patients' nutritional status.