Literature DB >> 21321691

A novel pH-responsive polysaccharidic ionic complex for proapoptotic D-(KLAKLAK)2 peptide delivery.

Bo Reum Lee1, Kyung Taek Oh, Young Taik Oh, Hye Jung Baik, So Young Park, Yu Seok Youn, Eun Seong Lee.   

Abstract

We report charge-switching ionic nanocomplexes comprised of glycol chitosan grafted with 2,3-dimethylmaleic acid (DMA) (denoted as 'GCS-g-DMA' hereafter) and a proapoptotic peptide. This system allowed for improved peptide delivery to tumor sites via a mechanism of selective peptide release when the pH was dropped from 7.4 to 6.8.

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Year:  2011        PMID： 21321691     DOI： 10.1039/c0cc03590d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

Review 1.  The use of therapeutic peptides to target and to kill cancer cells.

Authors:  R J Boohaker; M W Lee; P Vishnubhotla; J M Perez; A R Khaled
Journal:  Curr Med Chem       Date:  2012       Impact factor: 4.530

Review 2.  Nanopreparations for mitochondria targeting drug delivery system: Current strategies and future prospective.

Authors:  Zhenjie Wang; Weiling Guo; Xiao Kuang; Shanshan Hou; Hongzhuo Liu
Journal:  Asian J Pharm Sci       Date:  2017-05-24       Impact factor: 6.598

3.  Tumor pH-Responsive Nanocarriers With Light-Activatable Drug Release for Chemo-Photodynamic Therapy of Breast Cancer.

Authors:  Zhang Zhang; An Gao; Chunyang Sun
Journal:  Front Chem       Date:  2022-06-22       Impact factor: 5.545

4.  A charge-reversible nanocarrier using PEG-PLL (-g-Ce6, DMA)-PLA for photodynamic therapy.

Authors:  Chaemin Lim; Taehoon Sim; Ngoc Ha Hoang; Chan Eun Jung; Eun Seong Lee; Yu Seok Youn; Kyung Taek Oh
Journal:  Int J Nanomedicine       Date:  2017-08-24
  4 in total

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