BACKGROUND: Late preterm infants (34-37 weeks' gestation) are often perceived at similar risks for morbidity and mortality as term infants. OBJECTIVE: To compare the neurodevelopmental outcomes of late preterm to term infants. METHODS: Our study sample of 6300 term and 1200 late preterm infants came from the Early Childhood Longitudinal Study-Birth Cohort. We used general estimating equations to get weighted odds of having developmental delay, mental index scores (MDI) or psychomotor index scores (PDI) < 70, at 24 months of age. RESULTS: Late preterm infants compared with term infants had lower MDI (85 vs 89) and PDI (88 vs 92), both P < .0001, respectively. A higher proportion of late preterm infants compared with term infants had an MDI <70 (21% vs 16%; P < .0001). An equal number had PDIs <70 (6.1% vs 6.5%). After controlling for statistically significant and clinically relevant descriptive characteristics, late preterm infants still had higher odds of mental (odds ratio: 1.52 [95% confidence interval: 1.26-1.82] P < .0001) or physical (odds ratio: 1.56 [95% confidence interval: 1.30-1.89] P < .0001) developmental delay. CONCLUSIONS: Late preterm infants have poorer neurodevelopmental outcomes than term infants and have increased odds to have a mental and/or physical developmental delay.
BACKGROUND: Late preterm infants (34-37 weeks' gestation) are often perceived at similar risks for morbidity and mortality as term infants. OBJECTIVE: To compare the neurodevelopmental outcomes of late preterm to term infants. METHODS: Our study sample of 6300 term and 1200 late preterm infants came from the Early Childhood Longitudinal Study-Birth Cohort. We used general estimating equations to get weighted odds of having developmental delay, mental index scores (MDI) or psychomotor index scores (PDI) < 70, at 24 months of age. RESULTS: Late preterm infants compared with term infants had lower MDI (85 vs 89) and PDI (88 vs 92), both P < .0001, respectively. A higher proportion of late preterm infants compared with term infants had an MDI <70 (21% vs 16%; P < .0001). An equal number had PDIs <70 (6.1% vs 6.5%). After controlling for statistically significant and clinically relevant descriptive characteristics, late preterm infants still had higher odds of mental (odds ratio: 1.52 [95% confidence interval: 1.26-1.82] P < .0001) or physical (odds ratio: 1.56 [95% confidence interval: 1.30-1.89] P < .0001) developmental delay. CONCLUSIONS: Late preterm infants have poorer neurodevelopmental outcomes than term infants and have increased odds to have a mental and/or physical developmental delay.
Authors: Heather H Burris; Sheryl L Rifas-Shiman; Andrea Baccarelli; Letizia Tarantini; Caroline E Boeke; Ken Kleinman; Augusto A Litonjua; Janet W Rich-Edwards; Matthew W Gillman Journal: J Dev Orig Health Dis Date: 2012-06 Impact factor: 2.401
Authors: Bergen B Nelson; Rebecca N Dudovitz; Tumaini R Coker; Elizabeth S Barnert; Christopher Biely; Ning Li; Peter G Szilagyi; Kandyce Larson; Neal Halfon; Frederick J Zimmerman; Paul J Chung Journal: Pediatrics Date: 2016-07-18 Impact factor: 7.124
Authors: Heather H Burris; Linda J Van Marter; Thomas F McElrath; Patrik Tabatabai; Augusto A Litonjua; Scott T Weiss; Helen Christou Journal: Pediatr Res Date: 2013-10-11 Impact factor: 3.756
Authors: Erica T Wang; Lauren Ramos; Nina Vyas; Gaisu Bhasin; Charles F Simmons; Margareta D Pisarska Journal: J Matern Fetal Neonatal Med Date: 2018-03-20
Authors: Julia B Pitcher; Alysha M Riley; Sebastian H Doeltgen; Lisa Kurylowicz; John C Rothwell; Suzanne M McAllister; Ashleigh E Smith; Angela Clow; David J Kennaway; Michael C Ridding Journal: J Neurosci Date: 2012-11-14 Impact factor: 6.167
Authors: Julia B Pitcher; Luke A Schneider; Nicholas R Burns; John L Drysdale; Ryan D Higgins; Michael C Ridding; Theodore J Nettelbeck; Ross R Haslam; Jeffrey S Robinson Journal: J Physiol Date: 2012-09-10 Impact factor: 5.182