Literature DB >> 21320973

An integrated approach to diabetic retinopathy research.

Thomas W Gardner1, Steven F Abcouwer, Alistair J Barber, Gregory R Jackson.   

Abstract

This review discusses the pathophysiology of diabetic retinopathy related to direct effects of loss of insulin receptor action and metabolic dysregulation on the retina. The resulting sensory neuropathy can be diagnosed by structural and functional tests in patients with mild nonproliferative diabetic retinopathy. Research teams can collaborate to integrate ocular and systemic factors that impair vision and to design strategies to maintain retinal function in persons with diabetes mellitus. Evolving concepts may lead to inclusion of tests of retinal function in the detection of diabetic retinopathy and neuroprotective strategies to preserve vision for persons with diabetes.

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Year:  2011        PMID： 21320973      PMCID： PMC3086099          DOI： 10.1001/archophthalmol.2010.362

Source DB:  PubMed          Journal:  Arch Ophthalmol        ISSN： 0003-9950


  43 in total

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Authors:  J M BLOODWORTH
Journal:  Diabetes       Date:  1962 Jan-Feb       Impact factor: 9.461

2.  Diabetic retinopathy.

Authors:  J R WOLTER
Journal:  Am J Ophthalmol       Date:  1961-05       Impact factor: 5.258

3.  Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group.

Authors:  E Lieth; A J Barber; B Xu; C Dice; M J Ratz; D Tanase; J M Strother
Journal:  Diabetes       Date:  1998-05       Impact factor: 9.461

4.  Multifocal electroretinogram delays reveal local retinal dysfunction in early diabetic retinopathy.

Authors:  B Fortune; M E Schneck; A J Adams
Journal:  Invest Ophthalmol Vis Sci       Date:  1999-10       Impact factor: 4.799

5.  Psychophysical investigation of ganglion cell loss in early glaucoma.

Authors:  Paul G D Spry; Chris A Johnson; Steven L Mansberger; George A Cioffi
Journal:  J Glaucoma       Date:  2005-02       Impact factor: 2.503

6.  Diabetes reduces basal retinal insulin receptor signaling: reversal with systemic and local insulin.

Authors:  Chad E N Reiter; Xiaohua Wu; Lakshman Sandirasegarane; Makoto Nakamura; Kirk A Gilbert; Ravi S J Singh; Patrice E Fort; David A Antonetti; Thomas W Gardner
Journal:  Diabetes       Date:  2006-04       Impact factor: 9.461

7.  Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy.

Authors:  J Kyle Krady; Anirban Basu; Colleen M Allen; Yuping Xu; Kathryn F LaNoue; Thomas W Gardner; Steven W Levison
Journal:  Diabetes       Date:  2005-05       Impact factor: 9.461

8.  Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition.

Authors:  K Miyamoto; S Khosrof; S E Bursell; R Rohan; T Murata; A C Clermont; L P Aiello; Y Ogura; A P Adamis
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-14       Impact factor: 11.205

9.  The Ins2Akita mouse as a model of early retinal complications in diabetes.

Authors:  Alistair J Barber; David A Antonetti; Timothy S Kern; Chad E N Reiter; Rohit S Soans; J Kyle Krady; Steven W Levison; Thomas W Gardner; Sarah K Bronson
Journal:  Invest Ophthalmol Vis Sci       Date:  2005-06       Impact factor: 4.799

10.  Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin.

Authors:  A J Barber; E Lieth; S A Khin; D A Antonetti; A G Buchanan; T W Gardner
Journal:  J Clin Invest       Date:  1998-08-15       Impact factor: 14.808
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  34 in total

1.  Diabetic hyperglycemia reduces Ca2+ permeability of extrasynaptic AMPA receptors in AII amacrine cells.

Authors:  Áurea Castilho; Eirik Madsen; António F Ambrósio; Margaret L Veruki; Espen Hartveit
Journal:  J Neurophysiol       Date:  2015-07-08       Impact factor: 2.714

2.  Early neurodegeneration in the retina of type 2 diabetic patients.

Authors:  Hille W van Dijk; Frank D Verbraak; Pauline H B Kok; Marilette Stehouwer; Mona K Garvin; Milan Sonka; J Hans DeVries; Reinier O Schlingemann; Michael D Abràmoff
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-05-14       Impact factor: 4.799

Review 3.  Diabetic Microvascular Disease: An Endocrine Society Scientific Statement.

Authors:  Eugene J Barrett; Zhenqi Liu; Mogher Khamaisi; George L King; Ronald Klein; Barbara E K Klein; Timothy M Hughes; Suzanne Craft; Barry I Freedman; Donald W Bowden; Aaron I Vinik; Carolina M Casellini
Journal:  J Clin Endocrinol Metab       Date:  2017-12-01       Impact factor: 5.958

Review 4.  Key factors involved in obesity development.

Authors:  Zhiyou Wang; Daixiu Yuan; Yehui Duan; Shujuan Li; Shengzhen Hou
Journal:  Eat Weight Disord       Date:  2017-08-24       Impact factor: 4.652

Review 5.  Mechanistic Insights into Pathological Changes in the Diabetic Retina: Implications for Targeting Diabetic Retinopathy.

Authors:  Sayon Roy; Timothy S Kern; Brian Song; Caren Stuebe
Journal:  Am J Pathol       Date:  2016-11-12       Impact factor: 4.307

6.  Spatial frequency threshold and contrast sensitivity of an optomotor behavior are impaired in the Ins2Akita mouse model of diabetes.

Authors:  Nikolay P Akimov; René C Rentería
Journal:  Behav Brain Res       Date:  2011-09-28       Impact factor: 3.332

Review 7.  Neurodegeneration in the pathogenesis of diabetic retinopathy: molecular mechanisms and therapeutic implications.

Authors:  Maxwell S Stem; Thomas W Gardner
Journal:  Curr Med Chem       Date:  2013       Impact factor: 4.530

Review 8.  Diabetic retinopathy: current understanding, mechanisms, and treatment strategies.

Authors:  Elia J Duh; Jennifer K Sun; Alan W Stitt
Journal:  JCI Insight       Date:  2017-07-20

9.  NRF2 plays a protective role in diabetic retinopathy in mice.

Authors:  Zhenhua Xu; Yanhong Wei; Junsong Gong; Hongkwan Cho; James K Park; Ee-Rah Sung; Hu Huang; Lijuan Wu; Charles Eberhart; James T Handa; Yunpeng Du; Timothy S Kern; Rajesh Thimmulappa; Alistair J Barber; Shyam Biswal; Elia J Duh
Journal:  Diabetologia       Date:  2013-11-03       Impact factor: 10.122

10.  The neuroscience of diabetic retinopathy.

Authors:  David A Antonetti
Journal:  Vis Neurosci       Date:  2021-01-18       Impact factor: 3.241
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