AIMS: This study examined the contribution of transmissible risk, in conjunction with family and peer contextual factors during childhood and adolescence, on the development of cannabis use disorder in adulthood. DESIGN: The family high-risk design was used to recruit proband fathers with and without substance use disorder and track their sons longitudinally from late childhood to adulthood. SETTING: The families were recruited under the aegis of the Center for Education and Drug Abuse Research in Pittsburgh, Pennsylvania. PARTICIPANTS: The oldest son in the family was studied at ages 10-12, 16, 19 and 22 years. MEASUREMENTS: The transmissible liability index (TLI), along with measures of quality of the parent-child relationship, cooperative behavior at home, social attitudes and peer milieu were administered to model the developmental pathway to cannabis use disorder. FINDINGS: Affiliation with socially deviant peers and harboring non-normative attitudes (age 16) mediate the association between transmissible risk for substance use disorder (SUD) (age 10-12) and use of illegal drugs (age 19), leading to cannabis use disorder (age 22). CONCLUSIONS: Deviant socialization resulting from transmissible risk and poor parent-child relationship is integral to development of cannabis use disorder in young adulthood.
AIMS: This study examined the contribution of transmissible risk, in conjunction with family and peer contextual factors during childhood and adolescence, on the development of cannabis use disorder in adulthood. DESIGN: The family high-risk design was used to recruit proband fathers with and without substance use disorder and track their sons longitudinally from late childhood to adulthood. SETTING: The families were recruited under the aegis of the Center for Education and Drug Abuse Research in Pittsburgh, Pennsylvania. PARTICIPANTS: The oldest son in the family was studied at ages 10-12, 16, 19 and 22 years. MEASUREMENTS: The transmissible liability index (TLI), along with measures of quality of the parent-child relationship, cooperative behavior at home, social attitudes and peer milieu were administered to model the developmental pathway to cannabis use disorder. FINDINGS: Affiliation with socially deviant peers and harboring non-normative attitudes (age 16) mediate the association between transmissible risk for substance use disorder (SUD) (age 10-12) and use of illegal drugs (age 19), leading to cannabis use disorder (age 22). CONCLUSIONS: Deviant socialization resulting from transmissible risk and poor parent-child relationship is integral to development of cannabis use disorder in young adulthood.
Authors: Michael M Vanyukov; Levent Kirisci; Ralph E Tarter; Howard F Simkevitz; Galina P Kirillova; Brion S Maher; Duncan B Clark Journal: Neurosci Biobehav Rev Date: 2003-10 Impact factor: 8.989
Authors: Michael M Vanyukov; Ralph E Tarter; Levent Kirisci; Galina P Kirillova; Brion S Maher; Duncan B Clark Journal: Neurosci Biobehav Rev Date: 2003-10 Impact factor: 8.989
Authors: Rebecca L McNamee; Kathryn L Dunfee; Beatriz Luna; Duncan B Clark; William F Eddy; Ralph E Tarter Journal: Alcohol Clin Exp Res Date: 2008-03 Impact factor: 3.455
Authors: Tanya M M Button; Soo Hyun Rhee; John K Hewitt; Susan E Young; Robin P Corley; Michael C Stallings Journal: Drug Alcohol Depend Date: 2006-09-07 Impact factor: 4.492
Authors: Julia D Buckner; Norman B Schmidt; Alan R Lang; Jason W Small; Robert C Schlauch; Peter M Lewinsohn Journal: J Psychiatr Res Date: 2007-02-23 Impact factor: 4.791
Authors: Michael M Vanyukov; Levent Kirisci; Lisa Moss; Ralph E Tarter; Maureen D Reynolds; Brion S Maher; Galina P Kirillova; Ty Ridenour; Duncan B Clark Journal: Behav Genet Date: 2009-04-18 Impact factor: 2.805
Authors: Lauren R Few; Julia D Grant; Elliot C Nelson; Timothy J Trull; Richard A Grucza; Kathleen K Bucholz; Karin J H Verweij; Nicholas G Martin; Dixie J Statham; Pamela A F Madden; Andrew C Heath; Michael T Lynskey; Arpana Agrawal Journal: J Stud Alcohol Drugs Date: 2016-11 Impact factor: 2.582
Authors: Ralph E Tarter; Levent Kirisci; Ada Mezzich; Ty Ridenour; Diana Fishbein; Michelle Horner; Maureen Reynolds; Galina Kirillova; Michael Vanyukov Journal: Drug Alcohol Depend Date: 2012-02-25 Impact factor: 4.492
Authors: Brooke S G Molina; Christine A P Walther; JeeWon Cheong; Sarah L Pedersen; Elizabeth M Gnagy; William E Pelham Journal: Exp Clin Psychopharmacol Date: 2014-03-10 Impact factor: 3.157