BACKGROUND: Dramatic increases in survival rates have led to increased interest regarding the health related quality of life (HRQOL) of adolescent and young adult survivors of bone tumors. This study investigated HRQOL and physical disability in adolescent and young adult survivors of lower extremity bone tumors as a function of type of surgical intervention, gender, and age at assessment. PROCEDURE: Twenty-eight participants (age range 18-32 years) completed three generic and one disease-specific measures of HRQOL and a measure of physical disability. For analysis, surgical intervention was grouped into limb sparing surgeries (LS; allograft fusion and endoprosthesis) and ablative surgeries (AMP; amputation or Van Nes rotationplasty). Age at study was grouped into ≤ 25 years of age and ≥ 26 years of age. The MOS-SF-36, HUI2, HUI3, and EORTC-QLQ-C30 were used to measure HRQOL and the TESS was used to assess physical disability. RESULTS: Survivors reported HRQOL equivalent to the general population, with the exception of physical functioning. LS reported poorer HRQOL than AMP participants for emotional functioning and fatigue. Males reported better HRQOL compared with females for overall HRQOL, general health, physical functioning, and social functioning. Finally, younger participants generally reported better HRQOL than older participants for overall HRQOL and physical functioning. CONCLUSIONS: This study identifies LS surgical intervention, female gender and older age as risk factors for reduced HRQOL in adolescent and young adult survivors of lower extremity bone tumors. This study also provides information about what instrument may be most useful in identifying these specific difficulties and subgroups.
BACKGROUND: Dramatic increases in survival rates have led to increased interest regarding the health related quality of life (HRQOL) of adolescent and young adult survivors of bone tumors. This study investigated HRQOL and physical disability in adolescent and young adult survivors of lower extremity bone tumors as a function of type of surgical intervention, gender, and age at assessment. PROCEDURE: Twenty-eight participants (age range 18-32 years) completed three generic and one disease-specific measures of HRQOL and a measure of physical disability. For analysis, surgical intervention was grouped into limb sparing surgeries (LS; allograft fusion and endoprosthesis) and ablative surgeries (AMP; amputation or Van Nes rotationplasty). Age at study was grouped into ≤ 25 years of age and ≥ 26 years of age. The MOS-SF-36, HUI2, HUI3, and EORTC-QLQ-C30 were used to measure HRQOL and the TESS was used to assess physical disability. RESULTS: Survivors reported HRQOL equivalent to the general population, with the exception of physical functioning. LS reported poorer HRQOL than AMPparticipants for emotional functioning and fatigue. Males reported better HRQOL compared with females for overall HRQOL, general health, physical functioning, and social functioning. Finally, younger participants generally reported better HRQOL than older participants for overall HRQOL and physical functioning. CONCLUSIONS: This study identifies LS surgical intervention, female gender and older age as risk factors for reduced HRQOL in adolescent and young adult survivors of lower extremity bone tumors. This study also provides information about what instrument may be most useful in identifying these specific difficulties and subgroups.
Authors: Andreas F Mavrogenis; Caterina Novella Abati; Carlo Romagnoli; Pietro Ruggieri Journal: Clin Orthop Relat Res Date: 2012-01-24 Impact factor: 4.176
Authors: S Mohammad; L Hormaza; K Neighbors; P Boone; M Tierney; R K Azzam; Z Butt; E M Alonso Journal: Am J Transplant Date: 2012-05-08 Impact factor: 8.086
Authors: Adriaan Penson; Sylvia van Deuren; Ewald Bronkhorst; Ellen Keizer; Tom Heskes; Marieke J H Coenen; Judith G M Rosmalen; Wim J E Tissing; Helena J H van der Pal; Andrica C H de Vries; Marry M van den Heuvel-Eibrink; Sebastian Neggers; Birgitta A B Versluys; Marloes Louwerens; Margriet van der Heiden-van der Loo; Saskia M F Pluijm; Martha Grootenhuis; Nicole Blijlevens; Leontien C M Kremer; Eline van Dulmen-den Broeder; Hans Knoop; Jacqueline Loonen Journal: BMC Med Res Methodol Date: 2021-05-16 Impact factor: 4.615
Authors: M M Fidler; C Frobisher; J Guha; K Wong; J Kelly; D L Winter; E Sugden; R Duncan; J Whelan; R C Reulen; M M Hawkins Journal: Br J Cancer Date: 2015-05-19 Impact factor: 7.640
Authors: Sylvia van Deuren; Adriaan Penson; Eline van Dulmen-den Broeder; Martha A Grootenhuis; Margriet van der Heiden-van der Loo; Ewald Bronkhorst; Nicole M A Blijlevens; Nina Streefkerk; Jop C Teepen; Wim J E Tissing; Helena J H van der Pal; Marry M van den Heuvel-Eibrink; Birgitta A B Versluys; Dorine Bresters; Flora E van Leeuwen; Cécile M Ronckers; Leontien C M Kremer; Hans Knoop; Jacqueline J Loonen Journal: Cancer Date: 2021-11-01 Impact factor: 6.921