OBJECTIVE: In some herpes zoster (HZ) patients, one symptom is problematic; postherpetic neuralgia (PHN), a persistence of pain such as spontaneous pain and stimulus-evoked pain, allodynia or hyperpathia, for more than 6 months after healing of the vesicular eruptions. In our previous study, we reported the association between HLA alleles, HLA-A*33 and B*44, and PHN patients. In this study, we aim to refine the association of these alleles with PHN or HZ using higher-resolution HLA typing technique with an increased sample size. METHODS: HLA allele frequencies were compared in 70 PHN patients, 80 HZ patients, 52 HZ(-) patients, and 140 Japanese controls using HLA typing kits of SSOP protocols. RESULT AND CONCLUSION: The allele frequencies of HLA-A*3303, B*4403, and DRB1*1302 in PHN(+) patients were significantly higher than those in Japanese controls (P=0.00007, P=0.000002, and P=0.0003, respectively). The frequencies of above alleles in PHN(+) patients were also significantly higher than those in PHN(-) patients (P=0.03, P=0.006 and P=0.03, respectively). However, no association was found in comparison of HZ(+) patients and HZ(-). And the frequency of HLA-B*5101 in HZ(-) patients was significantly higher than those in HZ(+) and PHN(+) patients (P=0.003 and P=0.009, respectively) indicating that HLA-B*5101 functions as a protective allele to HZ.
OBJECTIVE: In some herpes zoster (HZ) patients, one symptom is problematic; postherpetic neuralgia (PHN), a persistence of pain such as spontaneous pain and stimulus-evoked pain, allodynia or hyperpathia, for more than 6 months after healing of the vesicular eruptions. In our previous study, we reported the association between HLA alleles, HLA-A*33 and B*44, and PHN patients. In this study, we aim to refine the association of these alleles with PHN or HZ using higher-resolution HLA typing technique with an increased sample size. METHODS: HLA allele frequencies were compared in 70 PHN patients, 80 HZ patients, 52 HZ(-) patients, and 140 Japanese controls using HLA typing kits of SSOP protocols. RESULT AND CONCLUSION: The allele frequencies of HLA-A*3303, B*4403, and DRB1*1302 in PHN(+) patients were significantly higher than those in Japanese controls (P=0.00007, P=0.000002, and P=0.0003, respectively). The frequencies of above alleles in PHN(+) patients were also significantly higher than those in PHN(-) patients (P=0.03, P=0.006 and P=0.03, respectively). However, no association was found in comparison of HZ(+) patients and HZ(-). And the frequency of HLA-B*5101 in HZ(-) patients was significantly higher than those in HZ(+) and PHN(+) patients (P=0.003 and P=0.009, respectively) indicating that HLA-B*5101 functions as a protective allele to HZ.
Authors: Susan G Dorsey; Cynthia L Renn; Mari Griffioen; Cameron B Lassiter; Shijun Zhu; Heather Huot-Creasy; Carrie McCracken; Anup Mahurkar; Amol C Shetty; Colleen K Jackson-Cook; Hyungsuk Kim; Wendy A Henderson; Leorey Saligan; Jessica Gill; Luana Colloca; Debra E Lyon; Angela R Starkweather Journal: PLoS One Date: 2019-05-16 Impact factor: 3.240
Authors: Pieter Meysman; Nicolas De Neuter; Esther Bartholomeus; George Elias; Johan Van den Bergh; Marie-Paule Emonds; Geert W Haasnoot; Steven Heynderickx; Johan Wens; Nele R Michels; Julien Lambert; Eva Lion; Frans H J Claas; Herman Goossens; Evelien Smits; Pierre Van Damme; Viggo Van Tendeloo; Philippe Beutels; Arvid Suls; Geert Mortier; Kris Laukens; Benson Ogunjimi Journal: Immunogenetics Date: 2017-12-01 Impact factor: 3.330
Authors: Oliver van Hecke; Peter R Kamerman; Nadine Attal; Ralf Baron; Gyda Bjornsdottir; David L H Bennett; Michael I Bennett; Didier Bouhassira; Luda Diatchenko; Roy Freeman; Rainer Freynhagen; Maija Haanpää; Troels S Jensen; Srinivasa N Raja; Andrew S C Rice; Ze'ev Seltzer; Thorgeir E Thorgeirsson; David Yarnitsky; Blair H Smith Journal: Pain Date: 2015-11 Impact factor: 7.926
Authors: Margarita Calvo; Alexander J Davies; Harry L Hébert; Greg A Weir; Elissa J Chesler; Nanna B Finnerup; Roy C Levitt; Blair H Smith; G Gregory Neely; Michael Costigan; David L Bennett Journal: Neuron Date: 2019-11-20 Impact factor: 17.173