| Literature DB >> 21318892 |
Alex R Khomutov1, Janne Weisell, Maxim A Khomutov, Nikolay A Grigorenko, Alina R Simonian, Merja R Häkkinen, Tuomo A Keinänen, Mervi T Hyvönen, Leena Alhonen, Sergey N Kochetkov, Jouko Vepsäläinen.
Abstract
Earlier unknown racemic β-methylspermidine (β-MeSpd) and γ-methylspermidine (γ-MeSpd) were -synthesized starting from crotononitrile or methacrylonitrile and putrescine. Lithium aluminum hydride reduction of the intermediate di-Boc-nitriles resulted in corresponding di-Boc-amines, which after deprotection gave target β- and γ-MeSpd's. To prepare α-MeSpd, the starting compound, 3-amino-1-butanol, was converted into N-Cbz-3-amino-1-butyl methanesulfonate, which alkylated putrescine to give (after deprotection of amino group) the required α-MeSpd. Novel β- and γ-MeSpd's in combination with earlier α-MeSpd are useful tools for studying enzymology and cell biology of polyamines.Entities:
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Year: 2011 PMID： 21318892 DOI： 10.1007/978-1-61779-034-8_29
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745