BACKGROUND: Epidemiologic and genetic studies of obstructive sleep apnoea (OSA) are limited by a lack of large-scale, well-characterized OSA cohorts. These studies require large sample size to provide adequate power to detect differences between groups. This study describes the development of such a cohort (The Western Australian Sleep Health Study) in OSA patients of Caucasian-European origin attending the only public sleep clinic in Western Australia (WA). AIMS: The main aim of the study is to phenotype 4,000 OSA patients in order to define the genetics of OSA and its co-morbidities. METHODS: Almost all underwent laboratory-based attended polysomnography (PSG). RESULTS: Currently complete data (questionnaire, biochemistry, DNA, and PSG) has been obtained on over 3,000 individuals and will reach the target of 4,000 individuals by the end of 2010. In a separate but related study, we have developed a sleep study database containing data from all patients who have undergone PSG at the sleep laboratory since its inception in 1988 until the present day (over 30,000 PSG studies representing data from approximately 20,000 individuals). In addition, data from both cohorts have been linked prospectively to statutory health data collected by the WA Department of Health. CONCLUSION: This study will be the largest sleep clinic cohort database internationally with access to genetic and epidemiological data. It is unique among sleep clinic cohorts because of its size, the breadth of data collected and the ability to link prospectively to statutory health data. It will be a major tool to comprehensively assess genetic and epidemiologic factors determining OSA and its co-morbidities.
BACKGROUND: Epidemiologic and genetic studies of obstructive sleep apnoea (OSA) are limited by a lack of large-scale, well-characterized OSA cohorts. These studies require large sample size to provide adequate power to detect differences between groups. This study describes the development of such a cohort (The Western Australian Sleep Health Study) in OSA patients of Caucasian-European origin attending the only public sleep clinic in Western Australia (WA). AIMS: The main aim of the study is to phenotype 4,000 OSA patients in order to define the genetics of OSA and its co-morbidities. METHODS: Almost all underwent laboratory-based attended polysomnography (PSG). RESULTS: Currently complete data (questionnaire, biochemistry, DNA, and PSG) has been obtained on over 3,000 individuals and will reach the target of 4,000 individuals by the end of 2010. In a separate but related study, we have developed a sleep study database containing data from all patients who have undergone PSG at the sleep laboratory since its inception in 1988 until the present day (over 30,000 PSG studies representing data from approximately 20,000 individuals). In addition, data from both cohorts have been linked prospectively to statutory health data collected by the WA Department of Health. CONCLUSION: This study will be the largest sleep clinic cohort database internationally with access to genetic and epidemiological data. It is unique among sleep clinic cohorts because of its size, the breadth of data collected and the ability to link prospectively to statutory health data. It will be a major tool to comprehensively assess genetic and epidemiologic factors determining OSA and its co-morbidities.
Authors: Kim L Ward; David R Hillman; Alan James; Alexandra P Bremner; Laila Simpson; Matthew N Cooper; Lyle J Palmer; Annette C Fedson; Sutapa Mukherjee Journal: J Clin Sleep Med Date: 2013-10-15 Impact factor: 4.062
Authors: Kim L Ward; Nigel McArdle; Alan James; Alexandra P Bremner; Laila Simpson; Matthew N Cooper; Lyle J Palmer; Annette C Fedson; Sutapa Mukherjee; David R Hillman Journal: J Clin Sleep Med Date: 2015-04-15 Impact factor: 4.062
Authors: Brian E Cade; Jiwon Lee; Tamar Sofer; Heming Wang; Man Zhang; Han Chen; Sina A Gharib; Daniel J Gottlieb; Xiuqing Guo; Jacqueline M Lane; Jingjing Liang; Xihong Lin; Hao Mei; Sanjay R Patel; Shaun M Purcell; Richa Saxena; Neomi A Shah; Daniel S Evans; Craig L Hanis; David R Hillman; Sutapa Mukherjee; Lyle J Palmer; Katie L Stone; Gregory J Tranah; Gonçalo R Abecasis; Eric A Boerwinkle; Adolfo Correa; L Adrienne Cupples; Robert C Kaplan; Deborah A Nickerson; Kari E North; Bruce M Psaty; Jerome I Rotter; Stephen S Rich; Russell P Tracy; Ramachandran S Vasan; James G Wilson; Xiaofeng Zhu; Susan Redline Journal: Genome Med Date: 2021-08-26 Impact factor: 15.266
Authors: Laila Simpson; Nigel McArdle; Peter R Eastwood; Kim L Ward; Matthew N Cooper; Annette C Wilson; David R Hillman; Lyle J Palmer; Sutapa Mukherjee Journal: J Clin Sleep Med Date: 2015-10-15 Impact factor: 4.062
Authors: Sarah Appleton; Tiffany Gill; Anne Taylor; Douglas McEvoy; Zumin Shi; Catherine Hill; Amy Reynolds; Robert Adams Journal: Int J Environ Res Public Health Date: 2018-05-07 Impact factor: 3.390
Authors: Brian E Cade; Han Chen; Adrienne M Stilp; Tin Louie; Sonia Ancoli-Israel; Raanan Arens; Richard Barfield; Jennifer E Below; Jianwen Cai; Matthew P Conomos; Daniel S Evans; Alexis C Frazier-Wood; Sina A Gharib; Kevin J Gleason; Daniel J Gottlieb; David R Hillman; W Craig Johnson; David J Lederer; Jiwon Lee; Jose S Loredo; Hao Mei; Sutapa Mukherjee; Sanjay R Patel; Wendy S Post; Shaun M Purcell; Alberto R Ramos; Kathryn J Reid; Ken Rice; Neomi A Shah; Tamar Sofer; Kent D Taylor; Timothy A Thornton; Heming Wang; Kristine Yaffe; Phyllis C Zee; Craig L Hanis; Lyle J Palmer; Jerome I Rotter; Katie L Stone; Gregory J Tranah; James G Wilson; Shamil R Sunyaev; Cathy C Laurie; Xiaofeng Zhu; Richa Saxena; Xihong Lin; Susan Redline Journal: PLoS Genet Date: 2019-04-16 Impact factor: 5.917
Authors: Cornelius A Rietveld; Sarah E Medland; Jaime Derringer; Jian Yang; Tõnu Esko; Nicolas W Martin; Harm-Jan Westra; Konstantin Shakhbazov; Abdel Abdellaoui; Arpana Agrawal; Eva Albrecht; Behrooz Z Alizadeh; Najaf Amin; John Barnard; Sebastian E Baumeister; Kelly S Benke; Lawrence F Bielak; Jeffrey A Boatman; Patricia A Boyle; Gail Davies; Christiaan de Leeuw; Niina Eklund; Daniel S Evans; Rudolf Ferhmann; Krista Fischer; Christian Gieger; Håkon K Gjessing; Sara Hägg; Jennifer R Harris; Caroline Hayward; Christina Holzapfel; Carla A Ibrahim-Verbaas; Erik Ingelsson; Bo Jacobsson; Peter K Joshi; Astanand Jugessur; Marika Kaakinen; Stavroula Kanoni; Juha Karjalainen; Ivana Kolcic; Kati Kristiansson; Zoltán Kutalik; Jari Lahti; Sang H Lee; Peng Lin; Penelope A Lind; Yongmei Liu; Kurt Lohman; Marisa Loitfelder; George McMahon; Pedro Marques Vidal; Osorio Meirelles; Lili Milani; Ronny Myhre; Marja-Liisa Nuotio; Christopher J Oldmeadow; Katja E Petrovic; Wouter J Peyrot; Ozren Polasek; Lydia Quaye; Eva Reinmaa; John P Rice; Thais S Rizzi; Helena Schmidt; Reinhold Schmidt; Albert V Smith; Jennifer A Smith; Toshiko Tanaka; Antonio Terracciano; Matthijs J H M van der Loos; Veronique Vitart; Henry Völzke; Jürgen Wellmann; Lei Yu; Wei Zhao; Jüri Allik; John R Attia; Stefania Bandinelli; François Bastardot; Jonathan Beauchamp; David A Bennett; Klaus Berger; Laura J Bierut; Dorret I Boomsma; Ute Bültmann; Harry Campbell; Christopher F Chabris; Lynn Cherkas; Mina K Chung; Francesco Cucca; Mariza de Andrade; Philip L De Jager; Jan-Emmanuel De Neve; Ian J Deary; George V Dedoussis; Panos Deloukas; Maria Dimitriou; Guðny Eiríksdóttir; Martin F Elderson; Johan G Eriksson; David M Evans; Jessica D Faul; Luigi Ferrucci; Melissa E Garcia; Henrik Grönberg; Vilmundur Guðnason; Per Hall; Juliette M Harris; Tamara B Harris; Nicholas D Hastie; Andrew C Heath; Dena G Hernandez; Wolfgang Hoffmann; Adriaan Hofman; Rolf Holle; Elizabeth G Holliday; Jouke-Jan Hottenga; William G Iacono; Thomas Illig; Marjo-Riitta Järvelin; Mika Kähönen; Jaakko Kaprio; Robert M Kirkpatrick; Matthew Kowgier; Antti Latvala; Lenore J Launer; Debbie A Lawlor; Terho Lehtimäki; Jingmei Li; Paul Lichtenstein; Peter Lichtner; David C Liewald; Pamela A Madden; Patrik K E Magnusson; Tomi E Mäkinen; Marco Masala; Matt McGue; Andres Metspalu; Andreas Mielck; Michael B Miller; Grant W Montgomery; Sutapa Mukherjee; Dale R Nyholt; Ben A Oostra; Lyle J Palmer; Aarno Palotie; Brenda W J H Penninx; Markus Perola; Patricia A Peyser; Martin Preisig; Katri Räikkönen; Olli T Raitakari; Anu Realo; Susan M Ring; Samuli Ripatti; Fernando Rivadeneira; Igor Rudan; Aldo Rustichini; Veikko Salomaa; Antti-Pekka Sarin; David Schlessinger; Rodney J Scott; Harold Snieder; Beate St Pourcain; John M Starr; Jae Hoon Sul; Ida Surakka; Rauli Svento; Alexander Teumer; Henning Tiemeier; Frank J A van Rooij; David R Van Wagoner; Erkki Vartiainen; Jorma Viikari; Peter Vollenweider; Judith M Vonk; Gérard Waeber; David R Weir; H-Erich Wichmann; Elisabeth Widen; Gonneke Willemsen; James F Wilson; Alan F Wright; Dalton Conley; George Davey-Smith; Lude Franke; Patrick J F Groenen; Albert Hofman; Magnus Johannesson; Sharon L R Kardia; Robert F Krueger; David Laibson; Nicholas G Martin; Michelle N Meyer; Danielle Posthuma; A Roy Thurik; Nicholas J Timpson; André G Uitterlinden; Cornelia M van Duijn; Peter M Visscher; Daniel J Benjamin; David Cesarini; Philipp D Koellinger Journal: Science Date: 2013-05-30 Impact factor: 47.728
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