Literature DB >> 21318079

Chemoenzymatic Synthesis of 2-Arachidonoylglycerol, An Endogenous Ligand for Cannabinoid Receptors.

Subramanian K Vadivel1, Kyle M Whitten, A Makriyannis.   

Abstract

A simple and efficient synthesis of 2-arachidonoyl glycerol, an endogenous agonist for cannabinoid receptors was achieved using Novozym 435, immobilized lipase from Candida Antarctica.

Entities:  

Year:  2011        PMID： 21318079      PMCID： PMC3035909          DOI： 10.1016/j.tetlet.2011.01.047

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  9 in total

1.  Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells.

Authors:  T Sugiura; S Kondo; S Kishimoto; T Miyashita; S Nakane; T Kodaka; Y Suhara; H Takayama; K Waku
Journal:  J Biol Chem       Date:  2000-01-07       Impact factor: 5.157

2.  Lipase-catalyzed synthesis of monoacylglycerol in a homogeneous system.

Authors:  Julieta B Monteiro; Maria G Nascimento; Jorge L Ninow
Journal:  Biotechnol Lett       Date:  2003-04       Impact factor: 2.461

Review 3.  The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.

Authors:  Didier M Lambert; Christopher J Fowler
Journal:  J Med Chem       Date:  2005-08-11       Impact factor: 7.446

4.  Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds.

Authors:  T Sugiura; T Kodaka; S Nakane; T Miyashita; S Kondo; Y Suhara; H Takayama; K Waku; C Seki; N Baba; Y Ishima
Journal:  J Biol Chem       Date:  1999-01-29       Impact factor: 5.157

5.  Anandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand.

Authors:  S K Goparaju; N Ueda; H Yamaguchi; S Yamamoto
Journal:  FEBS Lett       Date:  1998-01-23       Impact factor: 4.124

Review 6.  Endocannabinoids and the regulation of their levels in health and disease.

Authors:  Vincenzo Di Marzo; Stefania Petrosino
Journal:  Curr Opin Lipidol       Date:  2007-04       Impact factor: 4.776

Review 7.  Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand.

Authors:  Takayuki Sugiura; Seishi Kishimoto; Saori Oka; Maiko Gokoh
Journal:  Prog Lipid Res       Date:  2006-04-19       Impact factor: 16.195

8.  Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.

Authors:  R Mechoulam; S Ben-Shabat; L Hanus; M Ligumsky; N E Kaminski; A R Schatz; A Gopher; S Almog; B R Martin; D R Compton
Journal:  Biochem Pharmacol       Date:  1995-06-29       Impact factor: 5.858

9.  Highly efficient enzymatic synthesis of 2-monoacylglycerides and structured lipids and their production on a technical scale.

Authors:  Jan Pfeffer; Andreas Freund; Rachid Bel-Rhlid; Carl-Erik Hansen; Matthias Reuss; Rolf D Schmid; Steffen C Maurer
Journal:  Lipids       Date:  2007-07-11       Impact factor: 1.646
  9 in total
  4 in total

1.  Asymmetric synthesis of novel N-(1-phenyl-2,3-dihydroxypropyl)arachidonylamides and evaluation of their anti-inflammatory activity.

Authors:  Padmanabha V Kattamuri; Rebecca Salmonsen; Catherine McQuain; Sumner Burstein; Hao Sun; Guigen Li
Journal:  Life Sci       Date:  2012-07-20       Impact factor: 5.037

2.  Application of Chemoenzymatic Hydrolysis in the Synthesis of 2-Monoacylglycerols.

Authors:  Kyle M Whitten; Alexandros Makriyannis; Subramanian K Vadivel
Journal:  Tetrahedron       Date:  2012-05-05       Impact factor: 2.457

3.  Design and synthesis of novel prostaglandin E2 ethanolamide and glycerol ester probes for the putative prostamide receptor(s).

Authors:  Erin L Shelnut; Spyros P Nikas; David F Finnegan; Nan Chiang; Charles N Serhan; Alexandros Makriyannis
Journal:  Tetrahedron Lett       Date:  2015-03-11       Impact factor: 2.415

4.  2-Arachidonoylglycerol Synthesis: Facile and Handy Enzymatic Method That Allows to Avoid Isomerization.

Authors:  Roberta Ottria; Silvana Casati; Paola Rota; Pierangela Ciuffreda
Journal:  Molecules       Date:  2022-08-15       Impact factor: 4.927
  4 in total

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