Christopher Seungkyu Lee1, Arthur Cho, Kyu Sung Lee, Sung Chul Lee. 1. Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, Sodaemungu Shinchondong 134, Seoul 120-752, Korea. sunglee@yuhs.ac
Abstract
AIMS: To evaluate the prognostic value of positron emission tomography (PET) imaging in patients with choroidal melanoma. METHODS: We undertook a retrospective review of 40 consecutive patients with choroidal melanoma who underwent pretreatment whole-body PET, received either brachytherapy using ruthenium-106 plaque, enucleation or gamma knife radiotherapy, and had 1 year of follow-up. Metabolic activity of choroidal melanoma measured as standardised uptake value (SUV) by PET imaging was evaluated with respect to the survival of patients. RESULTS: SUV (p=0.003) and the largest basal diameter of the tumour (p=0.003) were significantly correlated with metastatic death (Cox proportional hazards regression). There was an inverse correlation between tumour metabolic activity and time to metastasis (p=0.049; linear regression). CONCLUSION: Metabolic activity by PET imaging significantly predicted the survival of patients with choroidal melanoma.
AIMS: To evaluate the prognostic value of positron emission tomography (PET) imaging in patients with choroidal melanoma. METHODS: We undertook a retrospective review of 40 consecutive patients with choroidal melanoma who underwent pretreatment whole-body PET, received either brachytherapy using ruthenium-106 plaque, enucleation or gamma knife radiotherapy, and had 1 year of follow-up. Metabolic activity of choroidal melanoma measured as standardised uptake value (SUV) by PET imaging was evaluated with respect to the survival of patients. RESULTS: SUV (p=0.003) and the largest basal diameter of the tumour (p=0.003) were significantly correlated with metastatic death (Cox proportional hazards regression). There was an inverse correlation between tumour metabolic activity and time to metastasis (p=0.049; linear regression). CONCLUSION: Metabolic activity by PET imaging significantly predicted the survival of patients with choroidal melanoma.
Authors: Maria Lucia Calcagni; Maria Vittoria Mattoli; Maria Antonietta Blasi; Gianluigi Petrone; Maria Grazia Sammarco; Luca Indovina; Antonino Mulè; Vittoria Rufini; Alessandro Giordano Journal: Eur J Nucl Med Mol Imaging Date: 2013-07-04 Impact factor: 9.236