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Literature DB >> 21316961

Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus.

Jun-Young Cho¹, Yun-Ju Kwon, Mi-Jin Sohn, Soon-Ja Seok, Won-Gon Kim.

Abstract

A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited Staphylococcus aureus enoyl-ACP reductase with an IC(50) of 6 μM and also showed antibacterial activity against S. aureus and MRSA.

Entities: Chemical Gene Species

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Year: 2011 PMID： 21316961 DOI： 10.1016/j.bmcl.2011.01.080

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

6 in total

Review 1. Mining Fatty Acid Biosynthesis for New Antimicrobials.

Authors: Christopher D Radka; Charles O Rock
Journal: Annu Rev Microbiol Date: 2022-06-01 Impact factor: 16.232

2. Chemical Constituents of the Culture Broth of Phellinus linteus and Their Antioxidant Activity.

Authors: Myeong-Seok Lee; Byung Soon Hwang; In-Kyoung Lee; Geon-Sik Seo; Bong-Sik Yun
Journal: Mycobiology Date: 2015-03-31 Impact factor: 1.858

3. Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells.

Authors: Shiow-Chyn Huang; Ping-Chung Kuo; Hsin-Yi Hung; Tai-Long Pan; Fu-An Chen; Tian-Shung Wu
Journal: Int J Mol Sci Date: 2016-05-06 Impact factor: 5.923

Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus.

Review 1. Mining Fatty Acid Biosynthesis for New Antimicrobials.

2. Chemical Constituents of the Culture Broth of Phellinus linteus and Their Antioxidant Activity.

3. Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells.

4. Neuraminidase Inhibitors from the Fermentation Broth of Phellinus linteus.

5. Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus.

6. Impact of Phellinus gilvus mycelia on growth, immunity and fecal microbiota in weaned piglets.