| Literature DB >> 21316759 |
Yiqun Zhang1, Hui Wei, Min Wang, Lei Huai, Yingchang Mi, Yizhi Zhang, Dong Lin, Bingcheng Liu, Wei Li, Chunlin Zhou, Qing Rao, Jianxiang Wang.
Abstract
Mutations of isocitrate dehydrogenase 1 (IDH1) have recently been reported in acute myeloid leukemia (AML). However, the characteristics of IDH1-mutated AML are still not known clearly. We analyzed 416 Chinese AML patients and found 28 patients (6.7%) carried this mutation. One homozygous IDH1 mutant in AML was found. The IDH1 mutations were associated with NPM1 mutations (P=0.043) and could coexist with recurrent transcription factor aberrations including AML1-ETO (6/50), PML-RARα (3/77) and CBFβ-MYH11 (1/15). For AML with AML1-ETO fusion gene, IDH1(mut) patients may have worse disease-free survival (DFS) than IDH1(wild-type) patients.Entities:
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Year: 2011 PMID： 21316759 DOI： 10.1016/j.leukres.2011.01.019
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156