Lisa J Moran1, Boyd J Strauss, Helena J Teede. 1. The Jean Hailes Clinical Research Unit, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia. lisa.moran@med.monash.edu.au
Abstract
OBJECTIVE: To assess the Finnish Diabetes Risk Score in polycystic ovary syndrome (PCOS) and in different phenotypes of PCOS and controls. DESIGN: Cross-sectional study. SETTING: General community. PATIENT(S): Overweight premenopausal women with National Institutes of Health (NIH) PCOS (n = 29), non-NIH PCOS (n = 25), or controls (n = 27). INTERVENTION(S): No intervention provided. MAIN OUTCOME MEASURE(S): Finnish Diabetes Risk Score, anthropometrics, oral glucose tolerance test (OGTT), glucose, insulin, and reproductive hormone levels. RESULT(S): The women with NIH PCOS had higher adiposity, abdominal adiposity and 120-minute OGTT glucose. The women with NIH and non-NIH PCOS had elevated 120-minute OGTT insulin compared with controls. The women with NIH (11.3 ± 0.7) and non-NIH PCOS (10.4 ± 0.7) had similar diabetes risk scores, but both had higher diabetes risk score compared with controls (7.6 ± 0.8) maintained on adjustment for age and body mass index (BMI). The women with NIH (4%) and non-NIH PCOS (12%) had a lower prevalence of low risk of diabetes scores compared with controls (50%). CONCLUSION(S): We report for the first time that women with NIH and non-NIH PCOS have similar Finnish Diabetes Risk Scores and elevated scores relative to controls independent of age and adiposity. Similar clinical screening and treatment practices for type 2 diabetes are warranted for both phenotypes of PCOS.
OBJECTIVE: To assess the Finnish Diabetes Risk Score in polycystic ovary syndrome (PCOS) and in different phenotypes of PCOS and controls. DESIGN: Cross-sectional study. SETTING: General community. PATIENT(S): Overweight premenopausal women with National Institutes of Health (NIH) PCOS (n = 29), non-NIH PCOS (n = 25), or controls (n = 27). INTERVENTION(S): No intervention provided. MAIN OUTCOME MEASURE(S): Finnish Diabetes Risk Score, anthropometrics, oral glucose tolerance test (OGTT), glucose, insulin, and reproductive hormone levels. RESULT(S): The women with NIH PCOS had higher adiposity, abdominal adiposity and 120-minute OGTT glucose. The women with NIH and non-NIH PCOS had elevated 120-minute OGTT insulin compared with controls. The women with NIH (11.3 ± 0.7) and non-NIH PCOS (10.4 ± 0.7) had similar diabetes risk scores, but both had higher diabetes risk score compared with controls (7.6 ± 0.8) maintained on adjustment for age and body mass index (BMI). The women with NIH (4%) and non-NIH PCOS (12%) had a lower prevalence of low risk of diabetes scores compared with controls (50%). CONCLUSION(S): We report for the first time that women with NIH and non-NIH PCOS have similar Finnish Diabetes Risk Scores and elevated scores relative to controls independent of age and adiposity. Similar clinical screening and treatment practices for type 2 diabetes are warranted for both phenotypes of PCOS.
Authors: Nigel K Stepto; Rhiannon K Patten; Eliza C Tassone; Marie L Misso; Leah Brennan; Jacqueline Boyle; Russell A Boyle; Cheryce L Harrison; Angelica Lindén Hirschberg; Kate Marsh; Alba Moreno-Asso; Leanne Redman; Mala Thondan; Chandrika Wijeyaratne; Helena J Teede; Lisa J Moran Journal: Sports Med Date: 2019-08 Impact factor: 11.136
Authors: Raymond J Rodgers; Jodie C Avery; Vivienne M Moore; Michael J Davies; Ricardo Azziz; Elisabet Stener-Victorin; Lisa J Moran; Sarah A Robertson; Nigel K Stepto; Robert J Norman; Helena J Teede Journal: Endocr Connect Date: 2019-03 Impact factor: 3.335