| Literature DB >> 21316226 |
Thomas S Reger1, Zhi-Qiang Yang, Kelly-Ann S Schlegel, Youheng Shu, Christa Mattern, Rowena Cube, Kenneth E Rittle, Georgia B McGaughey, George D Hartman, Cuyue Tang, Jeanine Ballard, Yuhsin Kuo, Thomayant Prueksaritanont, Cindy E Nuss, Scott M Doran, Steven V Fox, Susan L Garson, Yuxing Li, Richard L Kraus, Victor N Uebele, John J Renger, James C Barrow.
Abstract
A novel series of amide T-type calcium channel antagonists were prepared and evaluated using in vitro and in vivo assays. Optimization of the screening hit 3 led to identification of the potent and selective T-type antagonist 37 that displayed in vivo efficacy in rodent models of epilepsy and sleep.Entities:
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Year: 2011 PMID： 21316226 DOI： 10.1016/j.bmcl.2011.01.089
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823